影响蛔虫感染易感性的多个数量性状位点的定位
Localization of multiple quantitative trait loci influencing susceptibility to infection with Ascaris lumbricoides.
作者信息
Williams-Blangero Sarah, Vandeberg John L, Subedi Janardan, Jha Bharat, Corrêa-Oliveira Rodrigo, Blangero John
机构信息
Department of Genetics, Southwest Foundation for Biomedical Research, San Antonio, Texas 78245-0549, USA.
出版信息
J Infect Dis. 2008 Jan 1;197(1):66-71. doi: 10.1086/524060.
A linkage-based genome scan of 1,258 members of a single pedigree of the Jirel population of Nepal localized 6 potential quantitative trait loci (QTLs) influencing susceptibility to infection with Ascaris lumbricoides, the most common soil-transmitted intestinal helminth. Three QTLs exhibited genomewide significance, including QTLs on chromosomes 13 (logarithm of the odds ratio [LOD] score, 3.37; genomewide P = .013, 8 (LOD score, 3.03; genomewide P = .031), and 11 (LOD score, 3.19; genomewide P = .020). Another QTL on chromosome 1 approached significance (LOD score, 2.72; genomewide P = .067). There was suggestive evidence of linkage for 2 additional loci on chromosomes 1 and 13.
对尼泊尔吉雷尔人群一个单一家系的1258名成员进行的基于连锁分析的全基因组扫描，定位到6个影响感染蛔虫（最常见的土壤传播肠道蠕虫）易感性的潜在数量性状基因座（QTL）。三个QTL显示出全基因组显著性，包括位于13号染色体上的QTL（优势对数比[LOD]分数为3.37；全基因组P = 0.013）、8号染色体上的QTL（LOD分数为3.03；全基因组P = 0.031）和11号染色体上的QTL（LOD分数为3.19；全基因组P = 0.020）。1号染色体上的另一个QTL接近显著性（LOD分数为2.72；全基因组P = 0.067）。有提示性证据表明1号和13号染色体上还有另外2个基因座存在连锁。
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