Morokuma Seiichi, Doria Valentina, Ierullo Antonio, Kinukawa Naoko, Fukushima Kotaro, Nakano Hitoo, Arulkumaran Sabaratnam, Papageorghiou Aris T
Fetal Medicine Unit, Department of Obstetrics and Gynaecology, St George's Hospital, London University, UK.
Dev Sci. 2008 Jan;11(1):47-52. doi: 10.1111/j.1467-7687.2007.00646.x.
The aim of this study was to investigate developmental changes in heart rate response to repeated low-intensity (85 dB) sound stimulation in fetuses between 32 and 37 weeks of gestation. We measured amplitude changes in heart rate as our index of fetal response. At 35 to 37 weeks of gestation, the majority of fetuses showed a deceleratory response at the first trial. Amplitude decreased with further trials using the same stimulus before recovering when exposed to another type of stimulation. In contrast, responses in fetuses at 32 to 34 weeks of gestation were variable across trials and there was no recovery with exposure to another type of stimulation. Our results suggest that fetal habituation of cardiac response changes with developmental age.
本研究的目的是调查妊娠32至37周胎儿对反复低强度（85分贝）声音刺激的心率反应的发育变化。我们测量心率的幅度变化作为胎儿反应的指标。在妊娠35至37周时，大多数胎儿在第一次试验时表现出减速反应。在使用相同刺激进行进一步试验时，幅度会降低，而在暴露于另一种刺激时会恢复。相比之下，妊娠32至34周胎儿的反应在各试验中各不相同，并且在暴露于另一种刺激时不会恢复。我们的结果表明，胎儿心脏反应的习惯化随发育年龄而变化。
