Athanassiadou Pauline, Grapsa Dimitra, Athanassiades Peter, Gonidi Maria, Athanassiadou Anna-Maria, Tsipis Angelos, Patsouris Efstratios
Pathology Laboratory, Cytology Department, Medical School, Athens University, 75 Mikras Asias Street, 11527 Athens, Greece.
Pathol Res Pract. 2008;204(4):241-9. doi: 10.1016/j.prp.2007.11.004. Epub 2008 Jan 2.
We investigated the prognostic significance of cyclooxygenase-2 (COX-2) and survivin in ovarian carcinoma. Imprint smears were obtained from 100 ovarian carcinoma specimens and were studied immunocytochemically for the expression of COX-2 and survivin. The results were correlated with several clinicopathological parameters, including 5-year survival. Increased COX-2 staining pattern correlated with a non-mucinous histological type (p=0.008), increased stage (p<0.0001), high histological grade (p<0.0001), and reduced survival rates (p<0.00001). Survivin expression was strongly associated with increased stage (p<0.0001), increased histological grade (p<0.0001), and reduced survival (p<0.00001). Elevated survivin expression also correlated significantly with pre-menopausal status (p=0.033). In addition, COX-2 and survivin staining patterns correlated strongly with one another (p<0.0001). However, on multivariate analysis, an independent prognostic value was found only for tumor stage and grade. The findings of our study indicate that the increased expression of COX-2 and survivin in ovarian cancer is associated with one another and with several adverse clinicopathologic parameters, including reduced survival, thus suggesting a role of these molecules in disease progression. Further investigations of the exact prognostic and therapeutic implications of COX-2 and survivin expression are strongly warranted.
我们研究了环氧合酶-2（COX-2）和生存素在卵巢癌中的预后意义。从100例卵巢癌标本中获取印片涂片，并对其进行免疫细胞化学研究，以检测COX-2和生存素的表达。结果与包括5年生存率在内的多个临床病理参数相关。COX-2染色模式增加与非黏液性组织学类型相关（p = 0.008）、分期增加（p < 0.0001）、高组织学分级（p < 0.0001）以及生存率降低（p < 0.00001）。生存素表达与分期增加（p < 0.0001）、组织学分级增加（p < 0.0001）以及生存率降低（p < 0.00001）密切相关。生存素表达升高也与绝经前状态显著相关（p = 0.033）。此外，COX-2和生存素染色模式彼此密切相关（p < 0.0001）。然而，多因素分析显示，仅肿瘤分期和分级具有独立的预后价值。我们的研究结果表明，卵巢癌中COX-2和生存素表达增加彼此相关，且与包括生存率降低在内的多个不良临床病理参数相关，从而提示这些分子在疾病进展中发挥作用。强烈需要进一步研究COX-2和生存素表达的确切预后及治疗意义。
