Grabska-Barwinska Agnieszka, von der Malsburg Christoph
Institut für Neuroinformatik, Ruhr-Universität Bochum, 44780 Bochum, Germany.
J Neurosci. 2008 Jan 2;28(1):249-57. doi: 10.1523/JNEUROSCI.5514-06.2008.
In higher mammals, environmentally driven patterns of neural activity do not play a role in the establishment of orientation specificity and maps. It has been proposed that specific long-range interactions provide the scaffold for developing orientation maps. Our model aims at explaining how such a scaffold could develop in the first place. Broad spontaneous activity waves and locally evoked spatially periodic response pattern are used. The model is discussed in relation to biological evidence, and experiments to test the model are proposed. We show that reliable orientation specificity cannot be a result of haphazard cortical wiring, as has been proposed.
在高等哺乳动物中，环境驱动的神经活动模式在方向特异性和图谱的建立过程中并不起作用。有人提出，特定的长程相互作用为发育中的方向图谱提供了框架。我们的模型旨在解释这样一个框架最初是如何形成的。我们使用了广泛的自发活动波和局部诱发的空间周期性反应模式。结合生物学证据对该模型进行了讨论，并提出了测试该模型的实验。我们表明，可靠的方向特异性不可能像有人提出的那样，是随机皮质布线的结果。
