Posey David J, Stigler Kimberly A, Erickson Craig A, McDougle Christopher J
Christian Sarkine Autism Treatment Center, Department of Psychiatry, Indiana University School of Medicine, Indianapolis, Indiana 46202, USA.
J Clin Invest. 2008 Jan;118(1):6-14. doi: 10.1172/JCI32483.
Atypical antipsychotics have become indispensable in the treatment of a variety of symptoms in autism. They are frequently used to treat irritability and associated behaviors including aggression and self injury. They may also be efficacious for hyperactivity and stereotyped behavior. This review presents the rationale for the use of this drug class in autism and reviews the most important studies published on this topic to date. Significant adverse effects, including weight gain and the possibility of tardive dyskinesia, are reviewed. Future research directions are discussed.
非典型抗精神病药物在自闭症多种症状的治疗中已变得不可或缺。它们常被用于治疗易激惹及相关行为，包括攻击行为和自我伤害行为。它们对多动和刻板行为可能也有效。本综述阐述了在自闭症中使用这类药物的基本原理，并回顾了迄今为止关于该主题发表的最重要研究。还综述了包括体重增加和迟发性运动障碍可能性在内的显著不良反应。并讨论了未来的研究方向。
