Lee Kyu-Sung, Lee Hye Won, Han Deok Hyun
Department of Urology, Samsung Medical Center, Sungkyunkwan University School of Medicine, 50 Irwon-dong, Gangnam-gu, Seoul, 135-710, South Korea.
Naunyn Schmiedebergs Arch Pharmacol. 2008 Jun;377(4-6):491-501. doi: 10.1007/s00210-007-0242-y. Epub 2008 Jan 3.
This review discusses the available evidence concerning the use of anticholinergic drugs, alone or in combination with alpha-adrenoceptor antagonists, in men with lower urinary tract symptoms due to benign prostatic hyperplasia, benign prostatic enlargement, or benign prostatic obstruction and concomitant overactive bladder syndrome. We emphasize the safety and efficacy of anticholinergic agents in treating men with benign prostatic obstruction. Several recent studies of men with an overactive bladder suggest that combination therapy of anticholinergic and alpha-adrenoceptor antagonists improves the symptoms effectively without increasing the incidence of acute urinary retention.
本综述讨论了有关抗胆碱能药物单独使用或与α-肾上腺素能受体拮抗剂联合使用，用于治疗因良性前列腺增生、良性前列腺肿大或良性前列腺梗阻以及伴有膀胱过度活动症而出现下尿路症状的男性患者的现有证据。我们强调抗胆碱能药物在治疗良性前列腺梗阻男性患者中的安全性和有效性。最近几项针对膀胱过度活动症男性患者的研究表明，抗胆碱能药物与α-肾上腺素能受体拮抗剂的联合治疗可有效改善症状，且不会增加急性尿潴留的发生率。
