Shin Dong Ah, Kim Keung Nyun, Shin Hyun Cheol, Yoon Do Heum
Department of Neurosurgery, Spine and Spinal Cord Institute, Yonsei University College of Medicine, Seoul, Republic of Korea.
J Neurosurg Spine. 2008 Jan;8(1):39-43. doi: 10.3171/SPI-08/01/039.
The objective of this study was to evaluate the invasiveness of microendoscopic discectomy (MED) in comparison with microscopic discectomy (MD) by measuring serum levels of creatine phosphokinase (CPK)-MM and lactate dehydrogenase (LDH)-5, and by comparing visual analog scale (VAS) scores of postoperative pain.
This study included a group of 15 patients who underwent surgery using MED and 15 patients who underwent surgery using MD, both for single-level unilateral herniated nucleus pulposus. The CPK-MM and LDH-5 levels were measured at admission and after 1, 3, and 5 days postoperatively. Pain assessment was recorded using scores raging from 0 to 10 on a subjective VAS at admission and at 1, 3, and 5 days postoperatively.
The mean CPK-MM levels were lower for the MED group than for the MD group at both 3 (576.1 +/- 286.3 IU/L compared with 968.1 +/- 377.8 IU/L) and 5 days (348.1 +/- 231.0 IU/L compared with 721.7 +/- 463.2) postoperatively (p < 0.05). The mean VAS scores for postoperative back pain were lower in the MED group than in the MD group, both at 1 (3.3 +/- 2.3 compared with 5.8 +/- 1.5) and 5 days (1.9 +/- 1.1 compared with 3.6 +/- 1.1) postoperatively (p < 0.01).
The MED procedure is less invasive than MD, and causes less muscle damage and less back pain.
本研究的目的是通过测量血清肌酸磷酸激酶(CPK)-MM和乳酸脱氢酶(LDH)-5水平,并比较术后疼痛的视觉模拟量表(VAS)评分,来评估显微内镜下椎间盘切除术(MED)与显微镜下椎间盘切除术(MD)相比的侵袭性。
本研究纳入了15例行MED手术的患者和15例行MD手术的患者,两组均为单节段单侧髓核突出。在入院时以及术后1、3和5天测量CPK-MM和LDH-5水平。使用主观VAS在入院时以及术后1、3和5天记录疼痛评估,评分范围为0至10分。
MED组术后3天(分别为576.1±286.3 IU/L和968.1±377.8 IU/L)和5天(分别为348.1±231.0 IU/L和721.7±463.2)的平均CPK-MM水平低于MD组(p<0.05)。MED组术后1天(分别为3.3±2.3和5.8±1.5)和5天(分别为1.9±1.1和3.6±1.1)的术后背痛平均VAS评分低于MD组(p<0.01)。
MED手术的侵袭性低于MD,且造成的肌肉损伤和背痛更少。