Yarom Noam, Hirshberg Avraham, Buchner Amos
Department of Oral Pathology and Oral Medicine, Maurice and Gabriela Goldschleger School of Dental Medicine, Tel Aviv University, Tel Aviv, Israel.
Int J Dermatol. 2007 Dec;46(12):1232-6. doi: 10.1111/j.1365-4632.2007.03393.x.
Oral melanoacanthoma is a rare pigmented lesion characterized by sudden appearance and rapid radial growth, mimicking malignant melanoma. Oral melanoacanthoma may present as a solitary or multifocal lesion; however, the characteristics of these two clinical variants have never been addressed. In this study, we present an unusual case of multifocal oral melanoacanthoma and analyze cases of oral melanoacanthoma reported in the literature, with special emphasis on multifocal lesions.
A thorough MEDLINE search of the literature for cases of oral melanoacanthoma was performed. The demographic and clinical data, histologic features, and immunohistochemical findings were extracted from the full-text articles.
The literature search yielded 52 patients with 67 lesions. The addition of our case increased this number to 53 patients with 72 lesions, 43 of whom had solitary lesions and 10 of whom had multifocal lesions. There was a female predominance amongst the patients with solitary oral melanoacanthoma (3 : 1), whereas multifocal oral melanoacanthoma showed an equal gender distribution (1 : 1). Multifocal lesions tended to occur more frequently on the palate, and solitary lesions on the buccal mucosa.
Multifocal oral melanoacanthoma appears to demonstrate some demographic and clinical variations from the solitary type of lesion.
口腔黑素棘皮瘤是一种罕见的色素沉着性病变，其特征为突然出现并呈快速放射状生长，酷似恶性黑色素瘤。口腔黑素棘皮瘤可表现为单发性或多发性病变；然而，这两种临床类型的特征从未得到阐述。在本研究中，我们报告一例罕见的多发性口腔黑素棘皮瘤病例，并分析文献中报道的口腔黑素棘皮瘤病例，特别关注多发性病变。
通过全面检索MEDLINE数据库查找口腔黑素棘皮瘤病例的文献。从全文文章中提取人口统计学和临床数据、组织学特征及免疫组化结果。
文献检索得到52例患者共67个病变。加上我们的病例，病例数增加至53例患者共72个病变，其中43例为单发性病变，10例为多发性病变。单发性口腔黑素棘皮瘤患者中女性居多（3∶1），而多发性口腔黑素棘皮瘤患者性别分布均衡（1∶1）。多发性病变更倾向于发生在腭部，单发性病变则多见于颊黏膜。
多发性口腔黑素棘皮瘤似乎在人口统计学和临床特征方面与单发性病变存在一些差异。
