Kara Nurten, Aydin Fatma, Senturk Nilgün, Gunes Sezgin, Canturk M Tayyar, Bagci Hasan, Bek Yüksel, Turanli Ahmet Yasar
Department of Medical Biology and Genetics, Ondokuz Mayis University, Samsun, Turkey.
Int J Dermatol. 2007 Dec;46(12):1271-4. doi: 10.1111/j.1365-4632.2007.03324.x.
Psoriasis is a multifactorial disease in which genetic and inflammatory factors play important roles. Leptin is classified as a cytokine and plays an important role in the regulation of the T-helper response. A common polymorphism in the promoter of the human leptin gene (G-2548A) may have a role in the pathogenesis of psoriasis.
To investigate the association between psoriasis and leptin gene polymorphism (G-2548A).
The study involved 109 patients with psoriasis and 125 healthy controls. Analyses of G-2548A polymorphism of the leptin gene were made by the polymerase chain reaction-restriction fragment length polymorphism technique. The genotypes (GG, GA, and AA of leptin gene G-2548A) and alleles (G and A) were scored and the frequencies were estimated. The frequencies of alleles and genotypes in patients and controls were compared. The relationship between leptin gene polymorphism and the clinical features of the patients was analyzed.
Both genotype [odds ratio (OR), 0.921; 95% confidence interval (CI), 0.501-1.694; P = 0.792] and allele (OR, 0.864; 95% CI, 0.600-1.242; P = 0.429) frequencies were not significantly different between patient and control groups. In addition, there was no significant association between genotype and allele frequencies and the clinical characteristics of psoriasis.
In this case-control study, no evidence of association between the G-2548A variant of the leptin gene and psoriasis was found.
银屑病是一种多因素疾病，其中遗传和炎症因素起重要作用。瘦素被归类为一种细胞因子，在调节辅助性T细胞反应中起重要作用。人类瘦素基因启动子中的一个常见多态性（G-2548A）可能在银屑病的发病机制中起作用。
研究银屑病与瘦素基因多态性（G-2548A）之间的关联。
该研究纳入了109例银屑病患者和125例健康对照。采用聚合酶链反应-限制性片段长度多态性技术对瘦素基因的G-2548A多态性进行分析。对瘦素基因G-2548A的基因型（GG、GA和AA）和等位基因（G和A）进行评分并估计频率。比较患者和对照中等位基因和基因型的频率。分析瘦素基因多态性与患者临床特征之间的关系。
患者组和对照组之间的基因型[比值比（OR），0.921；95%置信区间（CI），0.501-1.694；P = 0.792]和等位基因（OR，0.864；95%CI，0.600-1.242；P = 0.429）频率均无显著差异。此外，基因型和等位基因频率与银屑病的临床特征之间也无显著关联。
在这项病例对照研究中，未发现瘦素基因的G-2548A变异与银屑病之间存在关联的证据。
