Kalaev Maxim, Smoot Mike, Ideker Trey, Sharan Roded
School of Computer Science, Tel Aviv University, Tel Aviv 69978, Israel.
Bioinformatics. 2008 Feb 15;24(4):594-6. doi: 10.1093/bioinformatics/btm630. Epub 2008 Jan 2.
The identification of protein complexes is a fundamental challenge in interpreting protein-protein interaction data. Cross-species analysis allows coping with the high levels of noise that are typical to these data. The NetworkBLAST web-server provides a platform for identifying protein complexes in protein-protein interaction networks. It can analyze a single network or two networks from different species. In the latter case, NetworkBLAST outputs a set of putative complexes that are evolutionarily conserved across the two networks.
NetworkBLAST is available as web-server at: www.cs.tau.ac.il/~roded/networkblast.htm.
蛋白质复合物的识别是解读蛋白质-蛋白质相互作用数据时面临的一项基本挑战。跨物种分析有助于应对这些数据中常见的高水平噪声。NetworkBLAST网络服务器提供了一个在蛋白质-蛋白质相互作用网络中识别蛋白质复合物的平台。它可以分析单个网络或来自不同物种的两个网络。在后一种情况下，NetworkBLAST会输出一组在两个网络中进化上保守的假定复合物。
NetworkBLAST可作为网络服务器在以下网址获取：www.cs.tau.ac.il/~roded/networkblast.htm。
