Amirzadegan Alireza, Davoodi Gholamreza, Boroumand Mohammad Ali, Darabyan Sirous, Dehkordi Maria Raissi, Goodarzynejad Hamidreza
Tehran Heart Center, Medical Sciences/University of Tehran, Tehran, Iran.
Indian J Med Sci. 2007 Dec;61(12):648-55.
Specific infectious agents have been found to be related to the pathogenesis of coronary atherosclerosis.
We assessed the possible association between angiographically proven coronary artery disease (CAD) and hepatitis B surface antibody (HBS Ab) seropositivity in a population with relatively high prevalence of hepatitis B virus (HBV) infection.
This was a cross-sectional study.
We analyzed data from 830 consecutive subjects undergoing coronary angiography, including angiographic results reported by two cardiologists for inter-observer reliability and assessment of HBS Ab status determined by enzyme-linked immunosorbent assay (ELISA).
Chi-square test or Fisher's exact test, independent two-sample t test and the Pearson's Correlation Coefficient test were used, as required. Statistics were performed using SPSS software version 13 (SPSS, Chicago, IL).
Two hundred forty-nine (30%) subjects had normal angiogram or minimal CAD, and 581 (70%) had significant CAD in at least one major coronary artery. In patients with CAD and in patients without angiographic evidence of significant atherosclerosis, 28.7% and 28.9% respectively were positive for HBV (P=0.954). Mean C-reactive protein levels in subjects with positive and negative HBS Ab were 10.77+/-8.37 mg/L versus 10.33+/-7.64 mg/L respectively (P=0.465). However, C-reactive protein levels in CAD group were significantly higher (P<0.001).
Our results suggested hepatitis B surface antibody seropositivity has no relationship with coronary artery disease. Moreover, no significant linear correlation exists between HBS Ab and C-reactive protein levels. However, as previously shown, C-reactive protein level in patients with coronary artery disease is significantly higher than in patients with normal coronary arteries.
已发现特定感染因子与冠状动脉粥样硬化的发病机制有关。
在乙型肝炎病毒（HBV）感染率相对较高的人群中，我们评估了经血管造影证实的冠状动脉疾病（CAD）与乙肝表面抗体（HBS Ab）血清学阳性之间的可能关联。
这是一项横断面研究。
我们分析了830例连续接受冠状动脉造影的受试者的数据，包括两位心脏病专家报告的血管造影结果以评估观察者间的可靠性，以及通过酶联免疫吸附测定（ELISA）确定的HBS Ab状态。
根据需要使用卡方检验或Fisher精确检验、独立两样本t检验和Pearson相关系数检验。使用SPSS软件版本13（SPSS，伊利诺伊州芝加哥）进行统计分析。
249例（30%）受试者血管造影正常或有轻度CAD，581例（70%）至少有一支主要冠状动脉存在显著CAD。在有CAD的患者和无显著动脉粥样硬化血管造影证据的患者中，HBV阳性率分别为28.7%和28.9%（P = 0.954）。HBS Ab阳性和阴性受试者的平均C反应蛋白水平分别为10.77±8.37mg/L和10.33±7.64mg/L（P = 0.465）。然而，CAD组的C反应蛋白水平显著更高（P<0.001）。
我们的数据表明乙肝表面抗体血清学阳性与冠状动脉疾病无关。此外，HBS Ab与C反应蛋白水平之间不存在显著的线性相关性。然而，如先前所示，冠状动脉疾病患者的C反应蛋白水平显著高于冠状动脉正常的患者。
