Immunology Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.
Infectious and Tropical Diseases Research Center, Tabriz University of Medical Sciences, PO Box 5165665931, Tabriz, Iran.
Eur J Clin Microbiol Infect Dis. 2018 Dec;37(12):2225-2233. doi: 10.1007/s10096-018-3370-z. Epub 2018 Sep 5.
Several risk factors have been described for the pathogenesis of atherosclerosis. Infectious diseases are suggested to be a causative factor, and some viruses have been studied for their relation with atherosclerotic diseases. Studies report two hypotheses, direct and indirect effects, for the role of viral infections in atherogenesis. Viruses are able to initiate atherosclerosis by two different pathways. They can exert their direct effects on atherogenesis by infecting vascular cells and then inducing inflammation in the endothelium and smooth muscle cells. Alternatively, they can also apply indirect effects by infecting non-vascular cells and inducing systemic inflammation. In this review, we consider the available data about the effects and correlations of DNA and RNA viruses on atherosclerosis.
已经描述了几种导致动脉粥样硬化发病机制的危险因素。传染病被认为是一个致病因素，一些病毒与动脉粥样硬化疾病的关系已被研究。研究报告了两种假说，即病毒感染在动脉粥样硬化形成中的直接和间接作用。病毒可以通过两种不同的途径引发动脉粥样硬化。它们可以通过感染血管细胞，然后在内皮细胞和平滑肌细胞中诱导炎症，从而对动脉粥样硬化产生直接作用。或者，它们也可以通过感染非血管细胞并诱导全身炎症来发挥间接作用。在这篇综述中，我们考虑了关于 DNA 和 RNA 病毒对动脉粥样硬化的作用和相关性的现有数据。
