McConville B J, Fogelson M H, Norman A B, Klykylo W M, Manderscheid P Z, Parker K W, Sanberg P R
Division of Child and Adolescent Psychiatry, University of Cincinnati College of Medicine, OH 45267-0559.
Am J Psychiatry. 1991 Jun;148(6):793-4. doi: 10.1176/ajp.148.6.793.
In an open, nonblind study, 10 patients with Tourette's disorder who were being treated with haloperidol were videotaped before, while, and after chewing nicotine gum. The frequency of tics was reduced significantly during the 30-minute gum-chewing period and during the 1 hour after gum chewing. Nicotine appears to potentiate haloperidol effects in patients with Tourette's disorder.
在一项开放性、非盲法研究中，对10名正在接受氟哌啶醇治疗的图雷特氏症患者在咀嚼尼古丁口香糖之前、期间和之后进行了录像。在咀嚼口香糖的30分钟期间以及咀嚼口香糖后的1小时内，抽搐频率显著降低。尼古丁似乎能增强氟哌啶醇对图雷特氏症患者的疗效。
