Bektas Mehmet, Altan Mehmet, Alkan Murat, Ormeci Necati, Soykan Irfan
Department of Gastroenterology, Ibni Sina Hospital, Ankara University Medical School, Ankara, Turkey.
Digestion. 2007;76(3-4):192-5. doi: 10.1159/000112645. Epub 2007 Dec 21.
Gastrointestinal (GI) involvement in Behçet's disease (BD) mainly appears in mucosa and affects 5-40% of patients, however the effects of the disease on lower esophageal sphincter (LES) pressure and esophageal contractions are not well known. The aims of this study were to evaluate esophageal motor function and to identify whether there was any specific motility pattern for patients with BD who had upper GI symptoms without endoscopic abnormality.
25 patients with BD, with a mean age of 43.1 (range 20-66) years, were admitted to our clinic whose main complaints were dyspeptic such as reflux, epigastric pain, vomiting and bloating. 25 healthy and age-matched individuals were also included in the study as controls. After one night fasting, LES pressure and esophageal contractions were measured.
Esophageal motor abnormalities were detected in 16% (4/25) of these patients with manometric studies (non-specific esophageal motor disorder in 1, esophageal hypomotility in 2, and LES hypotension in 1 patient); 16% (4/25) of these patients had endoscopic findings and overall 32% (8/25) of the cases showed esophageal pathology. All cases with esophageal motor abnormalities were suffering from reflux and endoscopy showed grade B esophagitis in 2 of these cases. Median LES pressure and LES relaxation were significantly lower in patients with BD compared to the control group (16.8 +/- 10.5 vs. 20.4 +/- 6.1, p = 0.02, and 92.1 +/- 10.1 vs. 96.4 +/- 4.5, p = 0.03 respectively).
Esophageal involvement in BD is significantly high. We propose manometric studies are necessary to evaluate esophageal manifestations in BD patients with esophageal symptoms even without endoscopic findings.
白塞病（BD）累及胃肠道（GI）主要表现为黏膜病变，影响5% - 40%的患者，然而该病对食管下括约肌（LES）压力和食管收缩的影响尚不明确。本研究旨在评估食管运动功能，并确定无内镜异常但有上消化道症状的BD患者是否存在特定的运动模式。
25例BD患者，平均年龄43.1岁（范围20 - 66岁），因反流、上腹部疼痛、呕吐和腹胀等消化不良症状入住我院。25名年龄匹配的健康个体也纳入研究作为对照。禁食一晚后，测量LES压力和食管收缩情况。
通过测压研究，这些患者中有16%（4/25）检测到食管运动异常（1例为非特异性食管运动障碍，2例为食管动力不足，1例为LES低血压）；这些患者中有16%（4/25）有内镜检查结果，总体32%（8/25）的病例显示有食管病变。所有有食管运动异常的病例均有反流症状，其中2例内镜检查显示为B级食管炎。与对照组相比，BD患者的LES压力中位数和LES松弛度显著降低（分别为16.8±10.5 vs. 20.4±6.1，p = 0.0
