Ankara University Medical School, Ibni Sina Hospital, Department of Gastroenterology, Ankara, Turkey.
Eur J Intern Med. 2010 Feb;21(1):21-4. doi: 10.1016/j.ejim.2009.10.009. Epub 2009 Nov 27.
Heterotopic gastric mucosa occurs as a flat island of red mucosa in the proximal third of the esophagus where it gives rise to the cervical inlet patch. The aims of this study were to investigate the esophageal motility pattern and 24-h pH profiles of patients with cervical inlet patch.
Thirty patients (16 women, mean age: 44.9 years, range: 23-72) diagnosed as having heterotopic gastric mucosa in the cervical esophagus with upper gastrointestinal symptoms had undergone esophageal motility testing and 24-h pH monitorisation with a double-channel pH probe.
Manometric investigation was abnormal in 7 patients (non-specific esophageal motor disorder in 4 patients, esophageal hypomotility in 1 patient, and hypotensive LES in 2 patients). Pathological acid reflux (pH<4) was found in 9 (30%) of 30 heterotopic gastric mucosa patients during pH monitorisation from the distal probe. Pathological acid reflux in the proximal esophagus (percentage of total time of pH<4) was seen in four of these nine patients. Only four of the 30 patients (13.3%) presented with "acid independent episodes" during the 24-h esophageal pH monitorisation.
Manometric investigation and 24-h pH monitorisation revealed that some of the patients with HGM have signs of esophageal motor dysfunction and "acid independent episodes" from the patches. These abnormalities may be responsible for some of the symptoms of HGM patients.
异位胃黏膜表现为食管近端三分之一处的平坦红色黏膜小岛，此处为食管入口斑。本研究旨在探讨食管入口斑患者的食管动力模式和 24 小时 pH 谱。
30 例（女性 16 例，平均年龄 44.9 岁，范围 23-72 岁）被诊断为颈段食管异位胃黏膜且有上消化道症状的患者接受了食管动力检查和双通道 pH 探头 24 小时 pH 监测。
7 例（4 例非特异性食管动力障碍、1 例食管低动力、2 例低压力食管下括约肌）患者的动力检查异常。在 30 例异位胃黏膜患者中，9 例（30%）在远端探头 pH 监测期间发现病理性酸反流（pH<4）。在这 9 例患者中，有 4 例近端食管出现病理性酸反流（pH<4 的总时间百分比）。在 30 例患者中，只有 4 例（13.3%）在 24 小时食管 pH 监测中出现“酸非依赖性发作”。
动力检查和 24 小时 pH 监测显示，部分 HGM 患者存在食管动力功能障碍和斑块处“酸非依赖性发作”的迹象。这些异常可能是 HGM 患者部分症状的原因。
