先天性巨细胞病毒感染筛查试验的评估
Evaluation of screening tests for congenital cytomegalovirus infection.
作者信息
Inoue Naoki, Koyano Shin
机构信息
Department of Virology I, National Institute of Infectious Diseases, Tokyo, Japan.
出版信息
Pediatr Infect Dis J. 2008 Feb;27(2):182-4. doi: 10.1097/INF.0b013e318161a2d5.
PMID:18174856
Abstract
Although the use of dried blood spots has been proposed for screening of newborns with congenital cytomegalovirus infection, viral loads in blood were significantly smaller than those in urine (P < 0.001), and DNA recovery from dried blood spots using the thermal shock procedure was inefficient. In contrast, our urine-based screening program identified asymptomatic cases with low viral loads in blood.
摘要
尽管有人提议使用干血斑来筛查先天性巨细胞病毒感染的新生儿，但血液中的病毒载量明显低于尿液中的病毒载量（P < 0.001），并且使用热休克程序从干血斑中回收DNA的效率很低。相比之下，我们基于尿液的筛查项目发现了血液中病毒载量较低的无症状病例。
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