线粒体前体蛋白分选的多种途径。
Multiple pathways for sorting mitochondrial precursor proteins.
作者信息
Bolender Natalia, Sickmann Albert, Wagner Richard, Meisinger Chris, Pfanner Nikolaus
机构信息
Institut für Biochemie und Molekularbiologie, Zentrum für Biochemie und Molekulare Zellforschung, Universität Freiburg, Germany.
出版信息
EMBO Rep. 2008 Jan;9(1):42-9. doi: 10.1038/sj.embor.7401126.
Abstract
Mitochondria import hundreds of different precursor proteins from the cytosol. More than 50% of mitochondrial proteins do not use the classical import pathway that is guided by amino-terminal presequences, but instead contain different types of internal targeting signals. Recent studies have revealed an unexpected complexity of the mitochondrial protein import machinery and have led to the discovery of new transport pathways. Here, we review the versatility of mitochondrial protein import and its connection to mitochondrial morphology, redox regulation and energetics.
摘要
线粒体从细胞质中导入数百种不同的前体蛋白。超过50%的线粒体蛋白不使用由氨基末端前导序列引导的经典导入途径，而是含有不同类型的内部靶向信号。最近的研究揭示了线粒体蛋白导入机制出人意料的复杂性，并导致了新运输途径的发现。在这里，我们综述线粒体蛋白导入的多样性及其与线粒体形态、氧化还原调节和能量学的联系。
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