Ladame Sylvain
Institut de Science et d'Ingénierie Supramoléculaires, Université Louis Pasteur, CNRS UMR 7006, 8, allée Gaspard Monge, BP 70028, 67083 Strasbourg Cédex, France.
Org Biomol Chem. 2008 Jan 21;6(2):219-26. doi: 10.1039/b714599c. Epub 2007 Oct 29.
Dynamic combinatorial chemistry makes use of reversible reactions between functionalised monomeric building blocks to generate a mixture of products (dimers or oligomers) under thermodynamic equilibrium. This system reorganises upon addition of a target so that species that bind to, and are therefore stabilised by the target, are favourably formed and are thus amplified. Since the mid-1990's, dynamic combinatorial chemistry has been successfully applied to the identification/selection of ion receptors, enzyme inhibitors, catalysts, materials and nucleic acid ligands. Although it is now established as a powerful tool with broad applications some intrinsic limitations appeared when working on systems of increasing complexity. We present here the most recent advances in the field of dynamic combinatorial chemistry that have been developed to overcome these limitations and explore new areas of application.
动态组合化学利用功能化单体构建单元之间的可逆反应，在热力学平衡条件下生成产物混合物（二聚体或低聚物）。加入靶标后，该体系会重新组织，使得与靶标结合并因此被靶标稳定的物种得以顺利形成并得到扩增。自20世纪90年代中期以来，动态组合化学已成功应用于离子受体、酶抑制剂、催化剂、材料及核酸配体的识别/筛选。尽管如今它已成为一种具有广泛应用的强大工具，但在处理日益复杂的体系时，仍出现了一些固有局限性。我们在此展示动态组合化学领域为克服这些局限性并探索新应用领域而取得的最新进展。
