Rozenman Mary M, McNaughton Brian R, Liu David R
Department of Chemistry and Chemical Biology, Harvard University, Cambridge, MA 02138, USA.
Curr Opin Chem Biol. 2007 Jun;11(3):259-68. doi: 10.1016/j.cbpa.2007.05.016. Epub 2007 Jun 4.
Molecular evolution has been widely applied in the laboratory to generate novel biological macromolecules. The principles underlying evolution have more recently been used to address problems in the chemical sciences, including the discovery of functional synthetic small molecules, catalysts, materials and new chemical reactions. The application of these principles in dynamic combinatorial chemistry and in efforts involving small molecule-nucleic acid conjugates has facilitated the evaluation of large numbers of candidate structures or reactions for desired characteristics. These early efforts suggest the promise of pairing evolutionary approaches with synthetic chemistry.
分子进化已在实验室中广泛应用，以生成新型生物大分子。进化背后的原理最近已被用于解决化学科学中的问题，包括功能性合成小分子、催化剂、材料及新化学反应的发现。这些原理在动态组合化学以及涉及小分子-核酸共轭物的研究中的应用，促进了对大量具有所需特性的候选结构或反应的评估。这些早期研究表明了将进化方法与合成化学相结合的前景。
