Clark D A
Department of Medicine, McMaster University, Hamilton, Ontario, Canada.
Crit Rev Immunol. 1991;11(3-4):215-47.
Nine areas of current controversy in the field of immunology of reproduction have been selected for discussion: (1) do antisperm antibodies cause infertility; (2) does cell mediated immunity cause infertility; (3) do antibodies cause spontaneous abortion; (4) is abortion due to rejection of the "fetal allograft"; (5) is altered antigen expression crucial for survival of the "fetal allograft"; (6) is abortion mediated by graft rejection mechanisms; (7) does locoregional suppression prevent abortion; (8) does immunization to prevent abortion and promote pregnancy act via immunotropism and cytokine cross-talk; (9) do immune responses prevent spontaneous abortion in humans? The reasons for debate and uncertainty are reviewed and current data considered in an attempt to arrive at the most likely answer to each question. Directions for future research are proposed where appropriate.
（1）抗精子抗体是否导致不孕；（2）细胞介导的免疫是否导致不孕；（3）抗体是否导致自然流产；（4）流产是否由于“胎儿同种异体移植物”的排斥反应；（5）抗原表达改变对“胎儿同种异体移植物”的存活是否至关重要；（6）流产是否由移植物排斥机制介导；（7）局部区域抑制是否能预防流产；（8）用于预防流产和促进妊娠的免疫接种是否通过免疫趋向性和细胞因子相互作用起作用；（9）免疫反应是否能预防人类自然流产？对存在争议和不确定性的原因进行了综述，并考虑了当前的数据，试图得出每个问题最可能的答案。在适当的地方提出了未来研究的方向。
