Nouza K, Kinský R, Dimitrov D
Institute for the Care of Mother and Child, Praha, Czech and Slovak Federal Republic.
Folia Biol (Praha). 1992;38(3-4):170-94.
This review is dealing with the roles of the immune system in the development and functions of the male and female reproductive systems. Further, it describes the topical views on the roles of immunopathologic events and mechanisms involved in the male and female infertility, recurrent abortions, endometriosis, EPH gestosis and disorders of fetal development. Particular attention is paid to the complicated immunological cross-talk and interplay between the mother and its offspring, including the active role played by the placenta and mainly the trophoblast tissue, in the course of gestation. In the light of the "immunotrophic theory", maternal immune responses to foreign fetal components, occurring in normal pregnancies, within the limits of "tolerated" or even beneficial levels, are described. Emphasis is given on the possible deregulation of materno-fetal immunological balance, leading to immunopathological events and putting in danger the overall reproductive capacity of the couple. The contemporary therapeutic--mainly immunological--approaches to the main reproductive failures are also mentioned.
本综述探讨免疫系统在男性和女性生殖系统发育及功能中的作用。此外，还描述了免疫病理事件和机制在男性和女性不育、反复流产、子宫内膜异位症、妊娠高血压综合征及胎儿发育障碍中的作用的相关热门观点。特别关注了孕期母亲与其后代之间复杂的免疫交互作用，包括胎盘尤其是滋养层组织所起的积极作用。根据“免疫营养理论”，描述了正常妊娠中母体对胎儿外来成分的免疫反应，这些反应处于“可耐受”甚至有益的水平范围内。重点关注了母胎免疫平衡可能出现的失调，这种失调会导致免疫病理事件，并危及夫妻的整体生殖能力。还提到了针对主要生殖功能障碍的当代治疗方法，主要是免疫治疗方法。
