用于铜催化二乙基锌加成到N-磺酰亚胺的N-杂环卡宾配体
N-heterocyclic carbene ligands in copper-catalyzed addition of diethylzinc to N-sulfonylimines.
作者信息
Md Abu Bakar, Suzuki Yumiko, Sato Masayuki
机构信息
School of Pharmaceutical Sciences, University of Shizuoka, Shizouka, Japan.
出版信息
Chem Pharm Bull (Tokyo). 2008 Jan;56(1):57-9. doi: 10.1248/cpb.56.57.
PMID:18175975
Abstract
N-Heterocyclic carbenes (NHCs) were generated in-situ from imidazolium and imidazolinium salts by deprotonation of C-2 hydrogen and were used as ligands in the copper-catalyzed addition of diethylzinc to N-sulfonylimines. The copper-NHC complexes were shown to possess an efficient ligand acceleration effect (LAE).
摘要
通过对 C-2 氢进行去质子化，从咪唑鎓盐和咪唑啉鎓盐原位生成 N-杂环卡宾（NHCs），并将其用作铜催化二乙基锌加成到 N-磺酰亚胺反应中的配体。结果表明，铜-NHC 配合物具有高效的配体加速效应（LAE）。
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