通过协同 ZnAr/Zn(CF) 组合实现的 -对甲苯磺酰亚胺的原子经济性芳基化。
Atom-efficient arylation of -tosylimines mediated by cooperative ZnAr/Zn(CF) combinations.
机构信息
Departement für Chemie, Biochemie und Pharmazie, Universität Bern, Bern 3012, Switzerland.
出版信息
Chem Commun (Camb). 2023 Jun 15;59(49):7583-7586. doi: 10.1039/d3cc01490h.
Abstract
By combining the Lewis acid Zn(CF) with nucleophilic diarylzinc (ZnAr) reagents, we report the atom-efficient arylation of -tosylimines under mild conditions. Mechanistic studies through the isolation of key intermediates reveal how the two zinc species act cooperatively to activate the imine substrate and regenerate the ZnAr reagent, enabling a limiting 50 mol% to be employed.
摘要
通过结合路易斯酸 Zn(CF)和亲核二芳基锌（ZnAr）试剂，我们在温和条件下实现了对 -甲苯磺酰亚胺的原子经济性芳基化。通过分离关键中间体进行的机理研究揭示了两种锌物种如何协同作用来活化亚胺底物并再生 ZnAr 试剂，从而使使用量限制在 50mol%。
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