Kaneshige Tatsuo, Saida Yuuto, Tanaka Ryou, Soda Aiko, Fukushima Akiko, Ida Nobutaka, Takenaka Masahiko, Yamane Yoshihisa
Department of Veterinary Surgery, Faculty of Agriculture, Tokyo University of Agriculture and Technology, Saiwai-cho, Tokyo, Japan.
J Vet Med Sci. 2007 Dec;69(12):1271-6. doi: 10.1292/jvms.69.1271.
Beraprost sodium (BPS) is an orally active prostacyclin analogue. The effects of BPS on the heart, including coronary circulation improvement, myocardial and vascular protection and anti-fibrosis effect on myocardium interstitium, have previously been demonstrated. However, the effects of BPS on hemodynamics, cardiac function and myocardial contractility in patients in the hypertrophic phase have not been clarified. Therefore, in the present study, the effects of BPS under long-term administration were investigated using the hypertension model of salt-sensitive Dahl rats. Six-week-old Dahl rats were divided into three groups, an 8% high salt diet group treated with BPS (BPS group), an untreated 8% high salt diet group (HHF group) and an untreated 0.3% low salt diet group (Control group), and observations were conducted until 17 weeks of age. In the BPS and HHF groups, the survival rates after 11 weeks of high salt diet intake were 87.5% and 47.1%, respectively (p<0.05). At 17 weeks of age, the atrial systolic peak velocity/early diastolic peak velocity and heart weight index of the BPS group decreased significantly compared with the HHF group (p<0.05). The HHF group exhibited significantly more severe myocardial fibrosis mainly in the endocardial layer of the left and right ventricles compared with the BPS and Control groups (p<0.05). In the present study, long-term BPS administration preserved diastolic function and prevented myocardial interstitial fibrosis in the non-compensatory phase. The results of the present study suggest that BPS is effective for treatment of hypertensive cardiac hypertrophy.
贝前列素钠（BPS）是一种口服活性前列环素类似物。此前已证实BPS对心脏的作用，包括改善冠脉循环、心肌和血管保护以及对心肌间质的抗纤维化作用。然而，BPS对肥厚期患者的血流动力学、心脏功能和心肌收缩性的影响尚未阐明。因此，在本研究中，使用盐敏感型Dahl大鼠高血压模型研究了长期给药时BPS的作用。将6周龄的Dahl大鼠分为三组，即接受BPS治疗的8%高盐饮食组（BPS组）、未治疗的8%高盐饮食组（HHF组）和未治疗的0.3%低盐饮食组（对照组），并观察至17周龄。在BPS组和HHF组中，高盐饮食摄入11周后的存活率分别为87.5%和47.1%（p<0.05）。在17周龄时，BPS组的心房收缩期峰值速度/舒张早期峰值速度和心脏重量指数与HHF组相比显著降低（p<0.05）。与BPS组和对照组相比，HHF组主要在左、右心室内膜层表现出明显更严重的心肌纤维化（p<0.05）。在本研究中，长期给予BPS可保留舒张功能并预防非代偿期的心肌间质纤维化。本研究结果表明，BPS对高血压性心脏肥大的治疗有效。
