Hypertension and Vascular Research Division, Department of Internal Medicine, Henry Ford Hospital, Detroit, MI 48202, USA.
Life Sci. 2011 Nov 7;89(19-20):671-6. doi: 10.1016/j.lfs.2011.07.025. Epub 2011 Aug 10.
Although the role of Cox-2 in the heart's response to physiologic stress remains controversial (i.e. expression in myocytes versus other resident myocardial cells) the ever expanding role of prostanoids in multiple models of heart failure cannot be denied. Due to the fact that prostanoids are metabolized rather quickly (half life of seconds to minutes) it is believed these signaling mediators act in a paracrine fashion at the site of production. Evidence to date is quite convincing that these bioactive lipid derivatives are involved in physiologic homeostatic regulation as well as beneficial and maladaptive ventricular remodeling in heart failure. Thus, this review will assess the direct contribution of each PG on remodeling in the left ventricle (e.g. hypertrophy, functional effects, and fibrosis).
尽管 Cox-2 在心脏对生理应激的反应中的作用仍存在争议（即，在心肌细胞与其他驻留心肌细胞中的表达），但前列腺素在多种心力衰竭模型中的作用不断扩大是不可否认的。由于前列腺素的代谢速度相当快（半衰期为数秒至数分钟），因此人们认为这些信号转导介质在产生部位以旁分泌的方式发挥作用。迄今为止的证据非常令人信服，这些生物活性脂质衍生物参与了生理稳态调节以及心力衰竭中有益和适应不良的心室重构。因此，本综述将评估每种 PG 对左心室重构的直接贡献（例如，肥大、功能效应和纤维化）。
