Deest Guillaume, Zehner Lawrence, Nicand Elisabeth, Gaudy-Graffin Catherine, Goudeau Alain, Bacq Yannick
Service d'Hépatogastroentérologie, Hôpital Trousseau, CHRU de Tours.
Gastroenterol Clin Biol. 2007 Dec;31(12):1095-7. doi: 10.1016/s0399-8320(07)78342-2.
Viral hepatitis E is an endemic infection in developing countries. Emerging cases of autochthonous hepatitis E have been observed in developed countries, especially in France. Transmission route of those cases remains unknown and contamination may occur from an animal reservoir. We report two new cases of hepatitis E simultaneously diagnosed in a couple after a trip in southern France. Diagnosis was based on detection of anti-HEV IgM and HEV RNA in sera of the two patients. Epidemiologic investigation revealed that the two patients had eaten undercooked pig meat four weeks before the onset of the jaundice. This report suggests that consumption of undercooked pork meat may be responsible for the contamination by hepatitis E virus in France as it was described in Japan.
戊型病毒性肝炎在发展中国家是一种地方性感染病。在发达国家，尤其是法国，已观察到出现了本土戊型肝炎病例。这些病例的传播途径仍然不明，可能是由动物宿主传播所致。我们报告了在法国南部旅行后，一对夫妇同时被诊断出患有戊型肝炎的两例新病例。诊断依据是在两名患者血清中检测到抗戊型肝炎病毒免疫球蛋白M（anti-HEV IgM）和戊型肝炎病毒核糖核酸（HEV RNA）。流行病学调查显示，这两名患者在黄疸出现前四周食用了未煮熟的猪肉。本报告表明，食用未煮熟的猪肉可能是法国戊型肝炎病毒感染的原因，正如在日本所描述的那样。
