Al-Samarrai Abdulmunaim H, Adaay Mohaisen H, Al-Tikriti Khudhair A, Al-Anzy Muayed M
Department of Biochemistry, College of Medicine, University of Tikrit, Tikrit, Iraq.
Saudi Med J. 2008 Jan;29(1):94-7.
To evaluate the levels of some essential elements in thalassemic patients in Mosul, Iraq.
One hundred and five thalassemic blood transfusion dependent children, 2.5-18 years of age attending Ibn-Al-Atheer teaching hospital in Mosul City, Iraq, during 2005, were used in this study. Fifty-four healthy subjects served as a control group. Patients were allocated in a non-randomized prospective cross-sectional hospital based study. Essential elements levels were estimated. The mean, standard deviation, correlation coefficient, and z-test were used. P-values <0.05 were considered statistically significant.
Low serum zinc, and magnesium, and high serum copper, and potassium levels were found among the 105 thalassemic patients compared to the 54 controls. Levels of calcium, phosphate, and sodium were within normal limits.
Fluctuations in the essential elements levels seem to be related to the different complications associated with the disease. Zinc deficiency may be attributed to hyperzincuria resulted from the release of Zn from hemolyzed red cells. Hypercupremia occurs in acute and chronic infections and hemochromatosis, which is a principal complication of thalassemia. Increased Na levels may be due to renal damage. Hypomagnesemia may occur due to hypoparathyroidism.
评估伊拉克摩苏尔地区地中海贫血患者体内某些必需元素的水平。
本研究纳入了2005年期间在伊拉克摩苏尔市伊本·阿西尔教学医院就诊的105名2.5至18岁依赖输血的地中海贫血儿童。54名健康受试者作为对照组。患者被纳入一项基于医院的非随机前瞻性横断面研究。对必需元素水平进行了评估。使用了均值、标准差、相关系数和z检验。P值<0.05被认为具有统计学意义。
与54名对照组相比，105名地中海贫血患者血清锌和镁水平较低，血清铜和钾水平较高。钙、磷和钠水平在正常范围内。
必需元素水平的波动似乎与该疾病相关的不同并发症有关。锌缺乏可能归因于溶血红细胞释放锌导致的高锌尿症。高铜血症发生于急慢性感染和血色素沉着症，而血色素沉着症是地中海贫血的主要并发症。钠水平升高可能是由于肾脏损伤。低镁血症可能是由于甲状旁腺功能减退所致。
