关节炎的基因治疗。
Gene therapy for arthritis.
作者信息
Traister Russell S, Hirsch Raphael
机构信息
Division of Rheumatology, Children's Hospital of Pittsburgh, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA.
出版信息
Mod Rheumatol. 2008;18(1):2-14. doi: 10.1007/s10165-007-0017-9. Epub 2008 Jan 5.
Abstract
Arthritis is among the leading causes of disability in the developed world. There remains no cure for this disease and the current treatments are only modestly effective at slowing the disease's progression and providing symptomatic relief. The clinical effectiveness of current treatment regimens has been limited by short half-lives of the drugs and the requirement for repeated systemic administration. Utilizing gene transfer approaches for the treatment of arthritis may overcome some of the obstacles associated with current treatment strategies. The present review examines recent developments in gene therapy for arthritis. Delivery strategies, gene transfer vectors, candidate genes, and safety are also discussed.
摘要
关节炎是发达国家致残的主要原因之一。这种疾病仍然无法治愈，目前的治疗方法在减缓疾病进展和提供症状缓解方面效果有限。当前治疗方案的临床有效性受到药物半衰期短以及需要重复全身给药的限制。利用基因转移方法治疗关节炎可能会克服一些与当前治疗策略相关的障碍。本综述探讨了关节炎基因治疗的最新进展。还讨论了递送策略、基因转移载体、候选基因和安全性。
相似文献
1
Gene therapy for arthritis.关节炎的基因治疗。
Mod Rheumatol. 2008;18(1):2-14. doi: 10.1007/s10165-007-0017-9. Epub 2008 Jan 5.
2
Current status of gene therapy for rheumatoid arthritis.类风湿关节炎基因治疗的现状
Curr Rheumatol Rep. 2008 Oct;10(5):398-404. doi: 10.1007/s11926-008-0064-z.
3
Recent developments in molecular therapeutic approaches for rheumatoid arthritis.类风湿关节炎分子治疗方法的最新进展。
Curr Opin Mol Ther. 2004 Aug;6(4):395-402.
4
Gene therapy for rheumatoid arthritis: current status and future prospects.类风湿关节炎的基因治疗：现状与展望。
BioDrugs. 2011 Dec 1;25(6):381-91. doi: 10.2165/11595490-000000000-00000.
5
Application of cellular gene therapy for rheumatoid arthritis.细胞基因疗法在类风湿性关节炎中的应用。
Mod Rheumatol. 2006;16(5):269-75. doi: 10.1007/s10165-006-0501-7.
6
Gene therapy for patients with rheumatoid arthritis.类风湿性关节炎患者的基因治疗。
Joint Bone Spine. 2006 Mar;73(2):169-76. doi: 10.1016/j.jbspin.2005.01.013. Epub 2005 Jun 23.
7
Arthritis: is the cure in your genes?
J Bone Joint Surg Am. 1999 Feb;81(2):152-7.
8
Gene therapy in rheumatoid arthritis: Strategies to select therapeutic genes.类风湿关节炎的基因治疗：治疗基因的选择策略。
J Cell Physiol. 2019 Aug;234(10):16913-16924. doi: 10.1002/jcp.28392. Epub 2019 Feb 26.
9
[Gene transfer immunotherapy in rheumatoid arthritis: perspectives].[类风湿关节炎中的基因转移免疫疗法：前景]
Rev Med Interne. 2001 Feb;22(2):163-71. doi: 10.1016/s0248-8663(00)00306-4.
10
Gene therapy in rheumatic diseases.风湿性疾病的基因治疗。
Best Pract Res Clin Rheumatol. 2001 Dec;15(5):771-88. doi: 10.1053/berh.2001.0193.
引用本文的文献
1
Regenerative medicine: Breaking Prometheus's curse for cartilage regeneration.
Nat Rev Rheumatol. 2017 Sep;13(9):516-518. doi: 10.1038/nrrheum.2017.116. Epub 2017 Jul 27.
2
Phytochemicals as potential antidotes for targeting NF-κB in rheumatoid arthritis.植物化学物质作为类风湿关节炎中靶向核因子κB的潜在解毒剂。
3 Biotech. 2017 Aug;7(4):253. doi: 10.1007/s13205-017-0888-1. Epub 2017 Jul 18.
3
Cytokine-modulating strategies and newer cytokine targets for arthritis therapy.用于关节炎治疗的细胞因子调节策略及新型细胞因子靶点
Int J Mol Sci. 2014 Dec 31;16(1):887-906. doi: 10.3390/ijms16010887.
4
Immunosuppressive exosomes: a new approach for treating arthritis.免疫抑制性外泌体：一种治疗关节炎的新方法。
Int J Rheumatol. 2012;2012:573528. doi: 10.1155/2012/573528. Epub 2012 Mar 6.
5
Getting arthritis gene therapy into the clinic.将关节炎基因疗法推向临床。
Nat Rev Rheumatol. 2011 Apr;7(4):244-9. doi: 10.1038/nrrheum.2010.193. Epub 2010 Dec 7.
6
Synthesis and evaluation of a well-defined HPMA copolymer-dexamethasone conjugate for effective treatment of rheumatoid arthritis.一种用于有效治疗类风湿性关节炎的明确的HPMA共聚物-地塞米松共轭物的合成与评价
Pharm Res. 2008 Dec;25(12):2910-9. doi: 10.1007/s11095-008-9683-3. Epub 2008 Jul 23.
本文引用的文献
1
Local delivery of beta interferon using an adeno-associated virus type 5 effectively inhibits adjuvant arthritis in rats.使用5型腺相关病毒进行β干扰素的局部递送可有效抑制大鼠佐剂性关节炎。
J Gen Virol. 2007 Jun;88(Pt 6):1717-1721. doi: 10.1099/vir.0.82603-0.
2
Prothymosin alpha lacking the nuclear localization signal as an effective gene therapeutic strategy in collagen-induced arthritis.缺乏核定位信号的前胸腺素α作为胶原诱导性关节炎的有效基因治疗策略
J Immunol. 2007 Apr 1;178(7):4688-94. doi: 10.4049/jimmunol.178.7.4688.
3
Reduction of arthritis following intra-articular administration of an adeno-associated virus serotype 5 expressing a disease-inducible TNF-blocking agent.关节内注射表达疾病诱导性肿瘤坏死因子阻断剂的5型腺相关病毒后关节炎的减轻
Ann Rheum Dis. 2007 Sep;66(9):1143-50. doi: 10.1136/ard.2006.064519. Epub 2007 Mar 15.
4
Concurrent gene therapy strategies effectively destroy synoviocytes of patients with rheumatoid arthritis.同步基因治疗策略可有效破坏类风湿性关节炎患者的滑膜细胞。
Rheumatology (Oxford). 2007 May;46(5):783-9. doi: 10.1093/rheumatology/kel448. Epub 2007 Feb 19.
5
Gene therapy with an improved doxycycline-regulated plasmid encoding a tumour necrosis factor-alpha inhibitor in experimental arthritis.在实验性关节炎中使用编码肿瘤坏死因子-α抑制剂的改良强力霉素调控质粒进行基因治疗。
Arthritis Res Ther. 2007;9(1):R7. doi: 10.1186/ar2113.
6
Amelioration of arthritis by intraarticular dominant negative Ikk beta gene therapy using adeno-associated virus type 5.使用5型腺相关病毒通过关节内注射显性负性Ikkβ基因疗法改善关节炎
Hum Gene Ther. 2006 Aug;17(8):821-32. doi: 10.1089/hum.2006.17.821.
7
Inhibition of angiogenesis by interleukin-4 gene therapy in rat adjuvant-induced arthritis.白细胞介素-4基因疗法对大鼠佐剂性关节炎血管生成的抑制作用
Arthritis Rheum. 2006 Aug;54(8):2402-14. doi: 10.1002/art.22034.
8
Reciprocal developmental pathways for the generation of pathogenic effector TH17 and regulatory T cells.致病性效应T辅助细胞17（TH17）和调节性T细胞产生的相互发育途径。
Nature. 2006 May 11;441(7090):235-8. doi: 10.1038/nature04753. Epub 2006 Apr 30.
9
Effects of viral interleukin 10 introduced by in vivo electroporation on arthrogen-induced arthritis in mice.体内电穿孔导入病毒白细胞介素10对小鼠关节源性关节炎的影响。
J Rheumatol. 2006 Mar;33(3):455-62.
10
Direct chitosan-mediated gene delivery to the rabbit knee joints in vitro and in vivo.壳聚糖直接介导的基因在兔膝关节的体内外递送
Biochem Biophys Res Commun. 2006 Mar 3;341(1):202-8. doi: 10.1016/j.bbrc.2005.12.171. Epub 2006 Jan 9.
Zotero 插件