Traister Russell S, Hirsch Raphael
Division of Rheumatology, Children's Hospital of Pittsburgh, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA.
Mod Rheumatol. 2008;18(1):2-14. doi: 10.1007/s10165-007-0017-9. Epub 2008 Jan 5.
Arthritis is among the leading causes of disability in the developed world. There remains no cure for this disease and the current treatments are only modestly effective at slowing the disease's progression and providing symptomatic relief. The clinical effectiveness of current treatment regimens has been limited by short half-lives of the drugs and the requirement for repeated systemic administration. Utilizing gene transfer approaches for the treatment of arthritis may overcome some of the obstacles associated with current treatment strategies. The present review examines recent developments in gene therapy for arthritis. Delivery strategies, gene transfer vectors, candidate genes, and safety are also discussed.
关节炎是发达国家致残的主要原因之一。这种疾病仍然无法治愈，目前的治疗方法在减缓疾病进展和提供症状缓解方面效果有限。当前治疗方案的临床有效性受到药物半衰期短以及需要重复全身给药的限制。利用基因转移方法治疗关节炎可能会克服一些与当前治疗策略相关的障碍。本综述探讨了关节炎基因治疗的最新进展。还讨论了递送策略、基因转移载体、候选基因和安全性。
