Carcagnì Maria Rosaria, De Aloe Giovambattista, D'Ascenzo Giuseppina, Rubegni Pietro, Fimiani Michele
Dipartimento di Medicina Clinica e Scienze Immunologiche, Sezione di Dermatologia, Siena, Italy.
J Dtsch Dermatol Ges. 2008 Jun;6(6):451-7. doi: 10.1111/j.1610-0387.2007.06591.x. Epub 2007 Dec 18.
Graft-versus-host disease (GvHD) is a common and often serious complication of hematopoietic stem cell transplantation. There are two major forms of GvHD: an acute form which develops in the first 100 days after HSCT, and a chronic form which develops later. Chronic GvHD is a multiorgan syndrome with many features of autoimmune diseases, such as sclerodermatous skin changes, cholestasis, pulmonary fibrosis, xerostomia, oral ulcerations, myositis and fasciitis. Unlike acute GvHD which is characterized by acute alloreactivity,the etiology of chronic GvHD is controversial and is believed to be either an extension of acute GvHD and/or a result of dysfunctional immune reconstitution with generation of autoantibodies and autoreactive T-cell clones. GvHD is usually treated with corticosteroids and other immunosuppressants which do not always succeed in arresting its evolution. Extracorporeal photochemotherapy has been used in patients with both acute and chronic GvHD.
移植物抗宿主病（GvHD）是造血干细胞移植常见且往往较为严重的并发症。GvHD主要有两种形式：一种是急性形式，在造血干细胞移植后的前100天内发生；另一种是慢性形式，在之后发生。慢性GvHD是一种多器官综合征，具有许多自身免疫性疾病的特征，如硬皮病样皮肤改变、胆汁淤积、肺纤维化、口干、口腔溃疡、肌炎和筋膜炎。与以急性同种异体反应性为特征的急性GvHD不同，慢性GvHD的病因存在争议，被认为要么是急性GvHD的延续和/或免疫重建功能失调并产生自身抗体和自身反应性T细胞克隆的结果。GvHD通常用皮质类固醇和其他免疫抑制剂治疗，但这些治疗并不总能成功阻止其进展。体外光化学疗法已用于急性和慢性GvHD患者。
