El-Khatib M F, Husari A, Jamaleddine G W, Ayoub C M, Bou-Khalil P
American University of Beirut, Departments of Anesthesiology, Beirut, Lebanon.
Eur J Anaesthesiol. 2008 Apr;25(4):275-9. doi: 10.1017/S0265021507003134. Epub 2008 Jan 7.
Partial obstruction of endotracheal tubes due to accumulation of secretions and mucus plugs can increase the tube resistance and subsequently impose increased resistive load on the patient. This study was performed to determine the changes in the resistance of endotracheal tubes of sizes 7.5, 8.0 and 8.5 mm with different degrees and locations of endotracheal tube narrowing.
Reductions of 10%, 25%, 50% and 75% in the endotracheal tube's cross-sectional areas were created at different sites along the axes of the tube connected to an artificial lung. While ventilating with a constant inspiratory flow, a 1 s end-inspiratory occlusion manoeuvre was applied and the resulting plateau pressure was determined. The resistance was calculated as (peak airway pressure--plateau pressure)/peak inspiratory flow.
Significant increases in the endotracheal tube's resistances were observed as the tube's cross-sectional area reduction was increased from 25% to 50% and from 50% to 75% for the 7.5 mm endotracheal tube, from 25% to 50% for the 8.0 mm endotracheal tube, and from 50% to 75% for the 8.5 mm endotracheal tube. Changes of the endotracheal tube resistances were not affected by the site of cross-sectional area reductions along the axes of the tubes.
For endotracheal tubes of sizes 7.5, 8.0 and 8.5 mm, significant changes in the tubes resistances are observed when the partial obstructions of the tubes exceed certain critical values. The location of the partial obstruction did not affect the changes in the endotracheal tube resistances.
由于分泌物和黏液栓积聚导致气管内导管部分阻塞,会增加导管阻力,进而给患者带来更大的阻力负荷。本研究旨在确定内径为7.5、8.0和8.5毫米的气管内导管在不同程度和位置变窄时的阻力变化。
在连接人工肺的气管内导管轴线上的不同部位,将导管横截面积分别减少10%、25%、50%和75%。在以恒定吸气流量通气时,进行1秒的吸气末阻断操作,并测定由此产生的平台压。阻力计算为(气道峰值压力 - 平台压)/ 吸气峰值流量。
对于7.5毫米气管内导管,当导管横截面积减少从25%增加到50%以及从50%增加到75%时,观察到气管内导管阻力显著增加;对于8.0毫米气管内导管,横截面积减少从25%增加到50%时阻力显著增加;对于8.5毫米气管内导管,横截面积减少从50%增加到75%时阻力显著增加。气管内导管阻力的变化不受沿导管轴线横截面积减少部位的影响。
对于内径为7.5、8.0和8.5毫米的气管内导管,当导管部分阻塞超过一定临界值时,观察到导管阻力有显著变化。部分阻塞的位置不影响气管内导管阻力的变化。