单纯疱疹病毒2型合并感染的产前血清学和生殖道证据与围产期HIV-1传播之间无关联。

No association between antepartum serologic and genital tract evidence of herpes simplex virus-2 coinfection and perinatal HIV-1 transmission.

作者信息

Chen Katherine T, Tuomala Ruth E, Chu Clara, Huang Meei-Li, Watts D Heather, Zorrilla Carmen D, Paul Mary, Hershow Ron, Larussa Philip

机构信息

Department of Obstetrics and Gynecology and Epidemiology, Columbia University, New York, NY 10032, USA.

出版信息

Am J Obstet Gynecol. 2008 Apr;198(4):399.e1-5. doi: 10.1016/j.ajog.2007.10.784. Epub 2008 Feb 21.

DOI:10.1016/j.ajog.2007.10.784

PMID:18177832

Abstract

OBJECTIVE

The purpose of this study was to assess the risk of perinatal HIV-1 transmission in women who are coinfected with herpes simplex virus-2 (HSV-2).

STUDY DESIGN

We performed a nested case-control study of 26 women whose HIV-1 was transmitted to their infants and 52 control subjects whose HIV-1 was not transmitted. We assessed antepartum serologic evidence of HSV-2 by HSV-2 serostatus and genital tract evidence of HSV-2 by presence of HSV-2 DNA.

RESULTS

There was no significant association between antepartum serologic evidence of HSV-2 coinfection and the risk of perinatal HIV-1 transmission. There was also no association between antepartum genital tract evidence of HSV-2 coinfection and risk of perinatal HIV-1 transmission.

CONCLUSION

Women who were infected with HIV-1 with antepartum serologic and genital tract evidence of HSV-2 coinfection did not appear to have an increased risk of perinatal HIV-1 transmission. However, further investigations are needed to assess HSV-2 reactivation and the risk of perinatal HIV-1 transmission at the time of delivery.

摘要