Berkkanoglu Murat, Isikoglu Mete, Arici Funda, Ozgur Kemal
Antalya IVF, Antalya, Turkey.
Fertil Steril. 2008 Dec;90(6):2112-5. doi: 10.1016/j.fertnstert.2007.10.018. Epub 2008 Jan 4.
To determine whether there is an optimal time period to perform intracytoplasmic sperm injection (ICSI)/embryo transfer cycle after hysteroscopic resection of an incomplete uterine septum.
A retrospective cohort study.
Private infertility clinic.
PATIENT(S): A total of 282 women, who had undergone an ICSI/embryo transfer cycle after hysteroscopic resection of an incomplete uterine septum (from May 6, 2003 to January 1, 2006).
INTERVENTION(S): One hundred thirty-three patients (group A) underwent an ICSI/embryo transfer cycle within 9 weeks after hysteroscopic resection of an incomplete uterine septum, 93 patients (group B) underwent an ICSI/embryo transfer cycle between 10 and 16 weeks after hysteroscopic resection of an incomplete uterine septum, and 56 patients (group C) underwent an ICSI/embryo transfer cycle more than 17 weeks after hysteroscopic resection of an incomplete uterine septum.
MAIN OUTCOME MEASURE(S): Peak E(2) levels, total recombinant FSH dosage, MII oocytes retrieved, number of embryos transferred, number of grade 1 embryo transferred, pregnancy rate (PR; positive hCG), clinical PR (positive fetal cardiac activity), implantation rate, and first trimester miscarriage rate.
RESULT(S): Pregnancy rates were 52.6%, 52.6%, and 46.4% for groups A, B, and C, respectively. Clinical PRs were 45.8%, 43.1%, and 41.1% for groups A, B, and C, respectively. Implantation rates were 21.1%, 17.6%, and 22.1% for groups A, B, and C, respectively. First trimester miscarriage rates were 6.4%, 7.9%, and 5.1% for groups A, B, and C, respectively. There were no significant differences in the etiology of infertility, age, length of infertility, previous spontaneous abortion rates, length of septum, peak serum E(2) concentration, total recombinant FSH dosage, total number of MII oocytes retrieved, number of embryos transferred, number of grade 1 embryos transferred, PRs, clinical PRs, implantation rates, and first trimester miscarriage rate between the three groups.
CONCLUSION(S): Starting an ICSI/embryo transfer cycle just after the hysteroscopic procedure does not result in any impairment in implantation rate or PR compared to those started 10 or more weeks after the operation.
确定在宫腔镜切除不完全子宫纵隔后进行卵胞浆内单精子注射（ICSI）/胚胎移植周期是否存在最佳时间段。
一项回顾性队列研究。
私立不孕不育诊所。
共有282名女性，她们在宫腔镜切除不完全子宫纵隔后接受了ICSI/胚胎移植周期（从2003年5月6日至2006年1月1日）。
133名患者（A组）在宫腔镜切除不完全子宫纵隔后9周内进行了ICSI/胚胎移植周期，93名患者（B组）在宫腔镜切除不完全子宫纵隔后10至16周进行了ICSI/胚胎移植周期，56名患者（C组）在宫腔镜切除不完全子宫纵隔后17周以上进行了ICSI/胚胎移植周期。
E(2)峰值水平、重组促卵泡素总剂量、回收的MII期卵母细胞数量、移植胚胎数量、移植的1级胚胎数量、妊娠率（PR；hCG阳性）、临床妊娠率（胎儿心脏活动阳性）、着床率和孕早期流产率。
A、B、C组的妊娠率分别为52.6%、52.6%和46.4%。A、B、C组的临床妊娠率分别为45.8%、43.1%和41.1%。A、B、C组的着床率分别为21.1%、17.6%和22.1%。A、B、C组的孕早期流产率分别为6.4%、7.9%和5.1%。三组在不孕病因、年龄、不孕时间、既往自然流产率、纵隔长度、血清E(2)峰值浓度、重组促卵泡素总剂量、回收的MII期卵母细胞总数、移植胚胎数量、移植的1级胚胎数量、妊娠率、临床妊娠率、着床率和孕早期流产率方面均无显著差异。
与术后10周或更长时间开始的ICSI/胚胎移植周期相比，在宫腔镜手术后立即开始ICSI/胚胎移植周期不会导致着床率或妊娠率受损。
