Kovacs Peter, Kovats Timea, Bernard Artur, Zadori Janos, Szmatona Gabor, Kaali Steven G
Kaali Institute IVF Center, Budapest, Hungary.
Fertil Steril. 2008 Dec;90(6):2133-7. doi: 10.1016/j.fertnstert.2007.10.015. Epub 2008 Jan 4.
To study serum and follicular fluid (FF) hormone levels after the administration of urinary or recombinant hCG to initiate the final stages of oocyte maturation during IVF.
Prospective randomized study between 250 microg of recombinant hCG and 7,500 IU of urinary hCG as the final trigger of ovulation during IVF.
Private IVF center.
PATIENT(S): Infertile women undergoing IVF/intracytoplasmic sperm injection (ICSI) using the long protocol and recombinant FSH.
INTERVENTION(S): IVF treatment. Serum and FF hormone measurements on the day of oocyte collection.
MAIN OUTCOME MEASURE(S): Serum and FF E(2), P, hCG, and T levels.
RESULT(S): Stimulation parameters, serum and follicular E(2), P, T, and hCG levels were similar in the recombinant and urinary hCG groups. The number of oocytes retrieved from follicles >14 mm, the proportion of mature oocytes, fertilization rate, and pregnancy rate (PR) were also comparable.
CONCLUSION(S): Recombinant and urinary hCG provided similar serum and follicular hormonal environments during the final stages of oocyte maturation. The IVF outcome parameters were also comparable. The two medications appear to be equally effective.
研究在体外受精（IVF）过程中，使用尿源性或重组人绒毛膜促性腺激素（hCG）启动卵母细胞成熟最后阶段后血清和卵泡液（FF）中的激素水平。
一项前瞻性随机研究，比较250微克重组hCG和7500国际单位尿源性hCG作为IVF期间排卵最终触发剂的效果。
私立IVF中心。
采用长方案和重组促卵泡素（FSH）进行IVF/卵胞浆内单精子注射（ICSI）的不孕女性。
IVF治疗。在卵母细胞采集日测定血清和FF中的激素。
血清和FF中的雌二醇（E₂）、孕酮（P）、hCG和睾酮（T）水平。
重组hCG组和尿源性hCG组的刺激参数、血清和卵泡中的E₂、P、T及hCG水平相似。从直径>14毫米的卵泡中获取的卵母细胞数量、成熟卵母细胞比例、受精率和妊娠率（PR）也相当。
在卵母细胞成熟的最后阶段，重组hCG和尿源性hCG提供了相似的血清和卵泡激素环境。IVF结局参数也相当。这两种药物似乎同样有效。
