Babalonis Shanna, Emurian Cleeve S, Martin Catherine A, Lile Joshua A, Kelly Thomas H
Department of Behavioral Science, University of Kentucky, Lexington, KY 40536-0086, USA.
Drug Alcohol Depend. 2008 Apr 1;94(1-3):276-80. doi: 10.1016/j.drugalcdep.2007.11.007.
Pre-clinical studies indicate that changes in progesterone levels across menstrual cycle phases modulate the behavioral effects of sedative drugs acting at GABA(A) receptor sites. In this study, seven healthy women learned to discriminate triazolam (0.25 mg/70 kg) from placebo. After acquiring the discrimination, a range of triazolam doses (0.00, 0.06, 0.12 and 0.25 mg/70 kg) was tested during the early follicular and mid-luteal menstrual cycle phases. During the mid-luteal phase, when progesterone levels were elevated, 0.12 mg/70 kg triazolam was identified as the active triazolam training dose (0.25 mg/70 kg), whereas 0.12 mg/70 kg triazolam was identified as placebo during the early follicular phase, when progesterone levels were low. Triazolam engendered prototypical sedative effects on subjective effect, performance and cardiovascular measures that were generally independent of cycle phase. These results suggest that the discriminative stimulus effects of the positive GABA(A) modulator, triazolam, are sensitive to menstrual cycle phase in healthy adult women.
临床前研究表明，月经周期各阶段孕酮水平的变化会调节作用于GABA(A)受体位点的镇静药物的行为效应。在本研究中，7名健康女性学会了区分三唑仑（0.25毫克/70千克）和安慰剂。在获得这种区分能力后，在卵泡早期和黄体中期月经周期阶段测试了一系列三唑仑剂量（0.00、0.06、0.12和0.25毫克/70千克）。在黄体中期，当孕酮水平升高时，0.12毫克/70千克三唑仑被确定为有效的三唑仑训练剂量（0.25毫克/70千克），而在卵泡早期，当孕酮水平较低时，0.12毫克/70千克三唑仑被确定为安慰剂。三唑仑对主观效应、行为表现和心血管指标产生了典型的镇静作用，这些作用通常与月经周期阶段无关。这些结果表明，阳性GABA(A)调节剂三唑仑的辨别刺激效应在健康成年女性中对月经周期阶段敏感。
