Hunsaker Michael R, Lee Bart, Kesner Raymond P
University of Utah, Department of Psychology, Salt Lake City, UT, USA.
Behav Brain Res. 2008 Apr 9;188(2):310-5. doi: 10.1016/j.bbr.2007.11.015. Epub 2007 Nov 29.
It has been suggested that the hippocampus mediates episodic memory processing involving snapshot memory and temporal sequence learning. To test this theory, rats learned trial-unique sequences of spatial locations along a runway box and were tested on recall by removing one of the locations in the sequence and making the rat choose the correct location to be rewarded. Once animals were able to reliably perform this episodic memory task, they received lesions to either CA3 or CA1. Animals with lesions to either CA3 or CA1 had difficulty with episodic memory processing, although CA1 lesioned animals had a much greater deficit. However, when animals were trained on a non-episodic version of the same task, hippocampal lesions had no effect. These results suggest that CA3 and CA1 both contribute to episodic memory processing since lesions to CA3 or CA1 result in an inability to process spatial information episodically, whereas they have no effect on non-episodic information processing.
有人提出，海马体介导涉及情景记忆和时间序列学习的情景记忆处理。为了验证这一理论，让大鼠学习沿着跑道箱的一系列独特的空间位置序列，并通过移除序列中的一个位置并让大鼠选择正确的位置以获得奖励来测试其回忆能力。一旦动物能够可靠地执行这项情景记忆任务，它们就会接受CA3或CA1区域的损伤。CA3或CA1区域受损的动物在情景记忆处理方面存在困难，尽管CA1区域受损的动物缺陷要大得多。然而，当动物接受同一任务的非情景版本训练时，海马体损伤没有影响。这些结果表明，CA3和CA1都有助于情景记忆处理，因为对CA3或CA1的损伤会导致无法进行情景性空间信息处理，而对非情景信息处理没有影响。
