Hoge Jennifer, Kesner Raymond P
Department of Psychology, University of Utah, 380 South 1530 East, Room 502, Salt Lake City, UT 84112, USA.
Neurobiol Learn Mem. 2007 Sep;88(2):225-31. doi: 10.1016/j.nlm.2007.04.013. Epub 2007 Jun 8.
Previous research in the dorsal CA1 and dorsal CA3 subregions of the hippocampus has been shown to play an important role in mediating temporal order memory for spatial location information. What is not known is whether the dorsal CA3 and dorsal CA1 subregions of the hippocampus are also involved in temporal order for visual object information. Rats with dorsal CA1, dorsal CA3 or control lesions were tested in a temporal order task for visual objects using an exploratory paradigm. The results indicated that the controls and the dorsal CA3 lesioned rats preferred the first rather then the last object they had explored previously, indicating good memory for temporal order of object presentation. In contrast, rats with dorsal CA1 lesions displayed a profound deficit in remembering the order of the visual object presentations in that they preferred the last object rather than the first. All three groups of rats preferred a novel object compared to a previously explored object suggesting normal detection of visual object novelty. The results suggest that only the dorsal CA1, but not dorsal CA3, region is critical for processing temporal information for visual objects without affecting the detection of new visual objects.
先前在海马体背侧CA1和背侧CA3亚区的研究表明，其在介导空间位置信息的时间顺序记忆中发挥着重要作用。目前尚不清楚的是，海马体的背侧CA3和背侧CA1亚区是否也参与视觉对象信息的时间顺序处理。对背侧CA1、背侧CA3损伤的大鼠或对照大鼠，采用探索范式在视觉对象的时间顺序任务中进行测试。结果表明，对照组和背侧CA3损伤的大鼠更喜欢它们之前探索的第一个对象，而不是最后一个对象，这表明它们对对象呈现的时间顺序有良好的记忆。相比之下，背侧CA1损伤的大鼠在记忆视觉对象呈现顺序方面表现出严重缺陷，因为它们更喜欢最后一个对象而不是第一个对象。与之前探索过的对象相比，所有三组大鼠都更喜欢新对象，这表明它们对视觉对象新颖性的检测正常。结果表明，只有背侧CA1区域，而不是背侧CA3区域，对于处理视觉对象的时间信息至关重要，且不会影响对新视觉对象的检测。
