Joyce Joseph A
Wesley Long Community Hospital Division, Moses Cone Health System, Greensboro, North Carolina, USA.
AANA J. 2007 Dec;75(6):437-44.
Acute onset of dyspnea, fever, hypotension, and cough during or soon after a blood or blood-product transfusion has been described in the literature since the early 1950s. Between 2003 and 2005, transfusion-related acute lung injury (TRALI) surpassed ABO incompatibility as the number one cause of transfusion-related mortality in the United States, as reported to the Food and Drug Administration. Prompt recognition and appropriate intervention are required to reduce mortality. Prevention of TRALI represents a complex challenge. There is no single intervention that will prevent every case of TRALI, but several interventions have been proposed to reduce the risk.
自20世纪50年代初以来，文献中就已描述了在输血或输血后不久出现的急性呼吸困难、发热、低血压和咳嗽症状。据美国食品药品监督管理局报告，在2003年至2005年期间，输血相关急性肺损伤（TRALI）超过ABO血型不相容性，成为美国输血相关死亡的首要原因。需要迅速识别并进行适当干预以降低死亡率。预防TRALI是一项复杂的挑战。没有单一的干预措施能够预防每一例TRALI，但已提出了几种干预措施来降低风险。
