Sise A, Friedenberg F K
Gastroenterology Section, Department of Medicine, Temple University School of Medicine, Philadelphia, PA, USA.
Obes Rev. 2008 May;9(3):194-203. doi: 10.1111/j.1467-789X.2007.00459.x. Epub 2007 Dec 30.
Obesity has been implicated as an important risk factor for the development of gastroesophageal reflux disease (GERD). A variety of physiological abnormalities have been described which likely contribute to the association of GERD and obesity. These abnormalities involve the oesophageal body, lower oesophageal sphincter and stomach. For obese patients with GERD, weight loss in conjunction with anti-secretory medications is first-line therapy. For those with severe obesity who fail medical weight loss treatment, bariatric surgery has been shown to be beneficial. On balance, Roux-en-Y gastric bypass is probably the most efficacious surgery for patients with morbid obesity suffering from concomitant GERD.
肥胖已被认为是胃食管反流病（GERD）发生的一个重要危险因素。已描述了多种生理异常情况，这些异常可能导致了GERD与肥胖之间的关联。这些异常涉及食管体部、食管下括约肌和胃。对于肥胖的。对于患有GERD的肥胖患者，减肥联合抗分泌药物是一线治疗方法。对于那些严重肥胖且药物减肥治疗失败的患者，减肥手术已被证明是有益的。总体而言，对于患有病态肥胖并伴有GERD的患者，Roux-en-Y胃旁路手术可能是最有效的手术。
