Saez J M, Avallet O, Lejeune H, Chatelain P G
INSERM U 307, Hôpital Debrousse, Lyon, France.
Horm Res. 1991;36(3-4):104-15. doi: 10.1159/000182142.
In addition to the well-established endocrine regulation of testicular functions by gonadotropins, many data accumulated in the last few years indicate that a local control is required for a normal production of androgens and spermatogenesis. In the present paper we review the cell-cell interactions between somatic and germ cells in the testis and their role on the function of each cell type. Also, we will present evidences indicating that some of these interactions are mediated by several growth factors produced and acting within the testis. Moreover, very often the production of these factors are under control of gonadotropins, and in turn the growth factors regulate the sensitivity of testicular cells to these hormones.
除了促性腺激素对睾丸功能已明确的内分泌调节作用外，过去几年积累的许多数据表明，雄激素的正常产生和精子发生需要局部调控。在本文中，我们综述了睾丸中体细胞与生殖细胞之间的细胞间相互作用及其对每种细胞类型功能的作用。此外，我们将展示证据表明，其中一些相互作用是由睾丸内产生并起作用的几种生长因子介导的。而且，这些因子的产生常常受促性腺激素的控制，反过来，生长因子又调节睾丸细胞对这些激素的敏感性。
