Department of Biochemistry & Molecular Biology, School of Life Sciences, Pondicherry University, Pondicherry, India.
Asian J Androl. 2010 Jul;12(4):468-79. doi: 10.1038/aja.2010.43. Epub 2010 Jun 21.
For centuries, plants and plant-based products have been used as a valuable and safe natural source of medicines for treating various ailments. The therapeutic potential of most of these plants could be ascribed to their anticancer, antidiabetic, hepatoprotective, cardioprotective, antispasmodic, analgesic and various other pharmacological properties. However, several commonly used plants have been reported to adversely affect male reproductive functions in wildlife and humans. The effects observed with most of the plant and plant-based products have been attributed to the antispermatogenic and/or antisteroidogenic properties of one or more active ingredients. This review discusses the detrimental effects of some of the commonly used plants on various target cells in the testis. A deeper insight into the molecular mechanisms of action of these natural compounds could pave the way for developing therapeutic strategies against their toxicity.
几个世纪以来，植物和植物产品一直被用作治疗各种疾病的有价值且安全的天然药物来源。这些植物中的大多数的治疗潜力可以归因于它们的抗癌、抗糖尿病、保肝、护心、抗痉挛、镇痛和各种其他药理特性。然而，据报道，一些常用的植物会对野生动物和人类的男性生殖功能产生不良影响。大多数植物和植物产品的观察到的效果归因于一种或多种活性成分的抗精子发生和/或抗甾体生成特性。这篇综述讨论了一些常用植物对睾丸中各种靶细胞的有害影响。深入了解这些天然化合物的作用机制可能为开发针对其毒性的治疗策略铺平道路。
