Munts Alexander G, Zijlstra Freek J, Nibbering Peter H, Daha Mohamed R, Marinus Johan, Dahan Albert, van Hilten Jacobus J
Department of Neurology, Leiden University Medical Centre, Leiden, The Netherlands.
Clin J Pain. 2008 Jan;24(1):30-4. doi: 10.1097/AJP.0b013e318156d961.
There is compelling evidence of central nervous system involvement in neuropathic pain and movement disorders in patients with complex regional pain syndrome (CRPS). Previously, elevated cerebrospinal fluid (CSF) levels of interleukin-1beta and interleukin-6 were found in CRPS patients with and without movement disorders. The aim of the present study was to replicate these findings and to search for additional CSF biomarkers in chronic CRPS patients with dystonia.
CSF samples of 20 patients and 29 controls who underwent spinal anesthesia for surgical interventions participated. We measured interleukin-1beta, interleukin-6, interferon-gamma inducible protein-10, RANTES (regulated upon activation, normal T-cell expressed and secreted), complement C3, mannose-binding lectin, complement C1q, soluble intercellular adhesion molecule-1, endothelin-1, nitric oxide, human lactoferrin, and hypocretin-1 levels in these samples.
No differences in the CSF levels of these effector mediators between patients and controls were found.
Our CSF findings do not support a role of a variety of inflammatory mediators or hypocretin-1 in chronic CRPS patients with dystonia.
有确凿证据表明复杂区域疼痛综合征（CRPS）患者的中枢神经系统参与了神经性疼痛和运动障碍。此前，在伴有和不伴有运动障碍的CRPS患者中均发现脑脊液（CSF）白细胞介素-1β和白细胞介素-6水平升高。本研究的目的是重复这些发现，并在患有肌张力障碍的慢性CRPS患者中寻找其他脑脊液生物标志物。
纳入了20例接受手术干预脊髓麻醉的患者和29例对照的脑脊液样本。我们测量了这些样本中白细胞介素-1β、白细胞介素-6、干扰素-γ诱导蛋白-10、调节激活正常T细胞表达和分泌因子（RANTES）、补体C3、甘露糖结合凝集素、补体C1q、可溶性细胞间黏附分子-1、内皮素-1、一氧化氮、人乳铁蛋白和食欲素-1的水平。
未发现患者与对照之间这些效应介质的脑脊液水平存在差异。
我们的脑脊液研究结果不支持多种炎症介质或食欲素-1在患有肌张力障碍的慢性CRPS患者中起作用。
