突出炎症生物标志物在复杂性区域疼痛综合征诊断和管理中的作用。
Highlighting the Role of Biomarkers of Inflammation in the Diagnosis and Management of Complex Regional Pain Syndrome.
机构信息
Center for Pain Medicine, Department of Anesthesiology, Erasmus MC University Medical Center Rotterdam, Rotterdam, The Netherlands.
Laboratory Medical Immunology, Department of Immunology, Erasmus MC University Medical Center Rotterdam, Rotterdam, The Netherlands.
出版信息
Mol Diagn Ther. 2019 Oct;23(5):615-626. doi: 10.1007/s40291-019-00417-x.
Abstract
Complex regional pain syndrome (CRPS) is characterized by continuous pain that is often accompanied by sensory, motor, vasomotor, sudomotor, and trophic disturbances. If left untreated, it can have a significant impact on the quality of life of patients. The diagnosis of CRPS is currently based on a set of relatively subjective clinical criteria: the New International Association for the Study of Pain clinical diagnostic criteria for CRPS. There are still no objective laboratory tests to diagnose CRPS and there is a great need for simple, objective, and easily measurable biomarkers in the diagnosis and management of this disease. In this review, we discuss the role of inflammation in the multi-mechanism pathophysiology of CRPS and highlight the application of potential biomarkers of inflammation in the diagnosis and management of this disease.
摘要
复杂性区域疼痛综合征（CRPS）的特征是持续疼痛，常伴有感觉、运动、血管舒缩、出汗和营养障碍。如果不加以治疗，它会对患者的生活质量产生重大影响。CRPS 的诊断目前基于一组相对主观的临床标准：新国际疼痛研究协会（IASP）CRPS 临床诊断标准。目前仍没有用于诊断 CRPS 的客观实验室检查，因此在诊断和管理这种疾病时非常需要简单、客观和易于测量的生物标志物。在这篇综述中，我们讨论了炎症在 CRPS 多机制病理生理学中的作用，并强调了炎症潜在生物标志物在该疾病的诊断和管理中的应用。
相似文献
1
Highlighting the Role of Biomarkers of Inflammation in the Diagnosis and Management of Complex Regional Pain Syndrome.突出炎症生物标志物在复杂性区域疼痛综合征诊断和管理中的作用。
Mol Diagn Ther. 2019 Oct;23(5):615-626. doi: 10.1007/s40291-019-00417-x.
2
Complex regional pain syndrome: are the IASP diagnostic criteria valid and sufficiently comprehensive?复杂性区域疼痛综合征：国际疼痛研究协会的诊断标准是否有效且足够全面？
Pain. 1999 Nov;83(2):211-9. doi: 10.1016/s0304-3959(99)00104-9.
3
[Complex regional pain syndrome].[复杂性区域疼痛综合征]
Z Rheumatol. 2017 May;76(4):335-347. doi: 10.1007/s00393-017-0299-z.
4
[How I treat? complex regional pain syndrome].[我如何治疗复杂性区域疼痛综合征？]
Rev Med Liege. 2016 Dec;71(12):531-536.
5
Complex regional pain syndrome - phenotypic characteristics and potential biomarkers.复杂性区域疼痛综合征 - 表型特征和潜在生物标志物。
Nat Rev Neurol. 2018 May;14(5):272-284. doi: 10.1038/nrneurol.2018.20. Epub 2018 Mar 16.
6
Spinal Cord Stimulation in Patients With Complex Regional Pain Syndrome: A Possible Target for Immunomodulation?脊髓刺激治疗复杂性区域疼痛综合征患者：免疫调节的一个可能靶点？
Neuromodulation. 2018 Jan;21(1):77-86. doi: 10.1111/ner.12704. Epub 2017 Oct 24.
7
Immunological aspects of the complex regional pain syndrome (CRPS).复杂区域疼痛综合征（CRPS）的免疫学方面。
Curr Pharm Des. 2012;18(29):4546-9. doi: 10.2174/138161212802502206.
8
Unilateral L4-dorsal root ganglion stimulation evokes pain relief in chronic neuropathic postsurgical knee pain and changes of inflammatory markers: part II whole transcriptome profiling.单侧 L4 背根神经节刺激可缓解慢性神经病理性术后膝关节痛，并改变炎症标志物：第二部分全转录组谱分析。
J Transl Med. 2019 Jun 19;17(1):205. doi: 10.1186/s12967-019-1952-x.
9
Complex Regional Pain Syndrome after Total Knee Arthroplasty is Rare and Misdiagnosis Potentially Hazardous-Prospective Study of the New Diagnostic Criteria in 100 Patients with No Cases Identified.全膝关节置换术后复杂性区域疼痛综合征罕见，误诊可能有害——对100例患者采用新诊断标准的前瞻性研究，未发现病例
J Knee Surg. 2018 Sep;31(8):797-803. doi: 10.1055/s-0037-1615746. Epub 2018 Jan 2.
10
Complex regional pain syndrome: the role of the psychiatrist as an expert witness.复杂性区域疼痛综合征：精神科医生作为专家证人的角色。
Med Sci Law. 2009 Oct;49(4):241-6. doi: 10.1258/rsmmsl.49.4.241.
引用本文的文献
1
Current and Evolving Concepts in the Management of Complex Regional Pain Syndrome: A Narrative Review.复杂区域疼痛综合征管理中的当前及不断发展的概念：一项叙述性综述
Diagnostics (Basel). 2025 Feb 3;15(3):353. doi: 10.3390/diagnostics15030353.
2
10. Complex regional pain syndrome.10. 复杂性区域疼痛综合征。
Pain Pract. 2025 Jan;25(1):e13413. doi: 10.1111/papr.13413. Epub 2024 Sep 11.
3
A brief review of complex regional pain syndrome and current management.复杂性区域疼痛综合征的简要回顾与当前治疗方法。
Ann Med. 2024 Dec;56(1):2334398. doi: 10.1080/07853890.2024.2334398. Epub 2024 Apr 3.
4
Transient immune activation without loss of intraepidermal innervation and associated Schwann cells in patients with complex regional pain syndrome.在复杂性区域疼痛综合征患者中，存在短暂的免疫激活而无表皮内神经支配和相关施万细胞的丧失。
J Neuroinflammation. 2024 Jan 17;21(1):23. doi: 10.1186/s12974-023-02969-6.
5
Different Types of Pain in Complex Regional Pain Syndrome Require a Personalized Treatment Strategy.复杂性区域疼痛综合征中不同类型的疼痛需要个性化的治疗策略。
J Pain Res. 2023 Dec 27;16:4379-4391. doi: 10.2147/JPR.S432209. eCollection 2023.
6
The complex regional pain syndrome: Diagnosis and management strategies.复杂区域性疼痛综合征：诊断与管理策略。
Neurosciences (Riyadh). 2023 Oct;28(4):211-219. doi: 10.17712/nsj.2023.4.20230034.
7
Evidence of a genetic background predisposing to complex regional pain syndrome type 1.存在导致 1 型复杂性区域疼痛综合征的遗传背景的证据。
J Med Genet. 2024 Jan 19;61(2):163-170. doi: 10.1136/jmg-2023-109236.
8
The Role of Neuroinflammation in Complex Regional Pain Syndrome: A Comprehensive Review.神经炎症在复杂性区域疼痛综合征中的作用：综述
J Pain Res. 2023 Sep 6;16:3061-3073. doi: 10.2147/JPR.S423733. eCollection 2023.
9
Prescription Trends in Complex Regional Pain Syndrome: A Retrospective Case-Control Study.复杂性区域疼痛综合征的处方趋势：一项回顾性病例对照研究。
Brain Sci. 2023 Jun 30;13(7):1012. doi: 10.3390/brainsci13071012.
10
Is there an association between serum soluble interleukin-2 receptor levels and syndrome severity in persistent Complex Regional Pain Syndrome?血清可溶性白细胞介素-2 受体水平与持续性复杂性区域疼痛综合征的严重程度是否有关？
Pain Med. 2023 Nov 2;24(11):1234-1243. doi: 10.1093/pm/pnad081.
本文引用的文献
1
Brain Metabolites and Peripheral Biomarkers Associated with Neuroinflammation in Complex Regional Pain Syndrome Using [11C]-(R)-PK11195 Positron Emission Tomography and Magnetic Resonance Spectroscopy: A Pilot Study.采用 [11C]-(R)-PK11195 正电子发射断层扫描和磁共振波谱研究复杂区域疼痛综合征的神经炎症相关脑代谢物和外周生物标志物：一项初步研究。
Pain Med. 2019 Mar 1;20(3):504-514. doi: 10.1093/pm/pny111.
2
The JAK1/JAK2- inhibitor ruxolitinib inhibits mast cell degranulation and cytokine release.JAK1/JAK2 抑制剂芦可替尼可抑制肥大细胞脱颗粒和细胞因子释放。
Clin Exp Allergy. 2018 Nov;48(11):1412-1420. doi: 10.1111/cea.13217. Epub 2018 Aug 3.
3
Autoantibodies Associated With Connective Tissue Diseases: What Meaning for Clinicians?自身抗体与结缔组织病相关：对临床医生有何意义？
Front Immunol. 2018 Mar 26;9:541. doi: 10.3389/fimmu.2018.00541. eCollection 2018.
4
Complex regional pain syndrome - phenotypic characteristics and potential biomarkers.复杂性区域疼痛综合征 - 表型特征和潜在生物标志物。
Nat Rev Neurol. 2018 May;14(5):272-284. doi: 10.1038/nrneurol.2018.20. Epub 2018 Mar 16.
5
Neuroinflammation and Central Sensitization in Chronic and Widespread Pain.慢性广泛性疼痛中的神经炎症和中枢敏化。
Anesthesiology. 2018 Aug;129(2):343-366. doi: 10.1097/ALN.0000000000002130.
6
Complex regional pain syndrome-up-to-date.复杂性区域疼痛综合征——最新进展
Pain Rep. 2017 Oct 5;2(6):e624. doi: 10.1097/PR9.0000000000000624. eCollection 2017 Nov.
7
Expansion of blood IgG B, T2, and regulatory T cells in patients with IgG-related disease.IgG 相关疾病患者血液中 IgG B、T2 和调节性 T 细胞的扩增。
J Allergy Clin Immunol. 2018 May;141(5):1831-1843.e10. doi: 10.1016/j.jaci.2017.07.024. Epub 2017 Aug 19.
8
Elevated Plasma Levels of sIL-2R in Complex Regional Pain Syndrome: A Pathogenic Role for T-Lymphocytes?复杂性区域疼痛综合征中可溶性白细胞介素-2受体的血浆水平升高：T淋巴细胞的致病作用？
Mediators Inflamm. 2017;2017:2764261. doi: 10.1155/2017/2764261. Epub 2017 May 28.
9
[11C]-(R)-PK11195 positron emission tomography in patients with complex regional pain syndrome: A pilot study.[11C]-(R)-PK11195正电子发射断层扫描在复杂性区域疼痛综合征患者中的应用：一项初步研究。
Medicine (Baltimore). 2017 Jan;96(1):e5735. doi: 10.1097/MD.0000000000005735.
10
The Emerging Role of HMGB1 in Neuropathic Pain: A Potential Therapeutic Target for Neuroinflammation.高迁移率族蛋白B1在神经性疼痛中的新作用：神经炎症的潜在治疗靶点
J Immunol Res. 2016;2016:6430423. doi: 10.1155/2016/6430423. Epub 2016 May 18.
Zotero 插件