突出炎症生物标志物在复杂性区域疼痛综合征诊断和管理中的作用。
Highlighting the Role of Biomarkers of Inflammation in the Diagnosis and Management of Complex Regional Pain Syndrome.
机构信息
Center for Pain Medicine, Department of Anesthesiology, Erasmus MC University Medical Center Rotterdam, Rotterdam, The Netherlands.
Laboratory Medical Immunology, Department of Immunology, Erasmus MC University Medical Center Rotterdam, Rotterdam, The Netherlands.
出版信息
Mol Diagn Ther. 2019 Oct;23(5):615-626. doi: 10.1007/s40291-019-00417-x.
Complex regional pain syndrome (CRPS) is characterized by continuous pain that is often accompanied by sensory, motor, vasomotor, sudomotor, and trophic disturbances. If left untreated, it can have a significant impact on the quality of life of patients. The diagnosis of CRPS is currently based on a set of relatively subjective clinical criteria: the New International Association for the Study of Pain clinical diagnostic criteria for CRPS. There are still no objective laboratory tests to diagnose CRPS and there is a great need for simple, objective, and easily measurable biomarkers in the diagnosis and management of this disease. In this review, we discuss the role of inflammation in the multi-mechanism pathophysiology of CRPS and highlight the application of potential biomarkers of inflammation in the diagnosis and management of this disease.
复杂性区域疼痛综合征（CRPS）的特征是持续疼痛，常伴有感觉、运动、血管舒缩、出汗和营养障碍。如果不加以治疗，它会对患者的生活质量产生重大影响。CRPS 的诊断目前基于一组相对主观的临床标准：新国际疼痛研究协会（IASP）CRPS 临床诊断标准。目前仍没有用于诊断 CRPS 的客观实验室检查，因此在诊断和管理这种疾病时非常需要简单、客观和易于测量的生物标志物。在这篇综述中，我们讨论了炎症在 CRPS 多机制病理生理学中的作用，并强调了炎症潜在生物标志物在该疾病的诊断和管理中的应用。
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