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弧菌属致病性的全球系统图谱绘制：一项基于PRISMA的聚类分析

Global systematic mapping of Vibrio species pathogenicity: A PRISMA-guided cluster-based analysis.

作者信息

Onohuean Hope, Nwodo Uchechukwu U

机构信息

Biopharmaceutics Unit, Department of Pharmacology and Toxicology, School of Pharmacy, Kampala International University Western Campus, Ishaka-Bushenyi, Uganda.

Biomolecules, Metagenomics, Endocrine and Tropical Disease Research Group (BMETDREG), Kampala International University, Western Campus, Ishaka-Bushenyi, Uganda.

出版信息

Medicine (Baltimore). 2025 Feb 28;104(9):e41664. doi: 10.1097/MD.0000000000041664.

DOI:10.1097/MD.0000000000041664
PMID:40020131
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11875588/
Abstract

BACKGROUND

A systematic global map on toxigenesis and genomic virulence of Vibrio spp. was analyzed for research progress to identify the emerging research patterns for establishing a database for designing future interventions.

METHOD

The databases (Web of Science and Scopus) were analyzed with Voxviewer software to map the global scale of Vibrio spp. or virulence toxin/genes publications and standardized using Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) strategies.

RESULTS

The results identified 1162 (Web of Science n = 620, Scopus n = 542), while 314 studies qualified for inclusion and were significantly analyzed on virulence toxin/genes. By co-citation analysis, 4-thematic clusters were developed from 6420 citations and a total reference of 9062. Cluster #1 (pathogenesis & virulence factors) and cluster #4 (host response factors) generated the utmost publications and citations (n = 40, 643) and the least (n = 7, 85) interest by the researcher. Whereas 8-thematic clusters were developed by bibliographic coupling technique analysis, cluster#1 and cluster#8 generated the utmost (n = 78, 1684) and least (n = 7, 81) publications and citations interest by the researcher.

CONCLUSIONS

Our findings suggest that Vibrio toxigenesis and virulence factors are a complex field requiring an interdisciplinary approach consisting of interconnected perspectives that have important consequences for academics and policymakers.

摘要

背景

分析了关于弧菌属产毒作用和基因组毒力的系统全球图谱，以了解研究进展，确定新兴研究模式，从而建立一个用于设计未来干预措施的数据库。

方法

使用Voxviewer软件分析数据库（Web of Science和Scopus），以绘制弧菌属或毒力毒素/基因出版物的全球规模，并采用系统评价和Meta分析的首选报告项目（PRISMA）策略进行标准化。

结果

结果确定了1162篇文献（Web of Science数据库中n = 620篇，Scopus数据库中n = 542篇），其中314项研究符合纳入标准，并对毒力毒素/基因进行了显著分析。通过共被引分析，从6420次引用和9062条参考文献中形成了4个主题聚类。聚类#1（发病机制和毒力因子）和聚类#4（宿主反应因子）产生的出版物和引用最多（n = 40, 643），而研究人员对其兴趣最少（n = 7, 85）。而通过文献耦合技术分析形成了8个主题聚类，聚类#1和聚类#8产生的出版物和引用最多（n = 78, 1684），研究人员对其兴趣最少（n = 7, 81）。

结论

我们的研究结果表明，弧菌属产毒作用和毒力因子是一个复杂的领域，需要一种跨学科方法，该方法由相互关联的观点组成，对学术界和政策制定者具有重要影响。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/704c/11875588/2cad67e692fe/medi-104-e41664-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/704c/11875588/1464508abca1/medi-104-e41664-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/704c/11875588/16a52ac12385/medi-104-e41664-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/704c/11875588/1b447a7885e3/medi-104-e41664-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/704c/11875588/1b851feb03b2/medi-104-e41664-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/704c/11875588/2cad67e692fe/medi-104-e41664-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/704c/11875588/1464508abca1/medi-104-e41664-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/704c/11875588/16a52ac12385/medi-104-e41664-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/704c/11875588/1b447a7885e3/medi-104-e41664-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/704c/11875588/1b851feb03b2/medi-104-e41664-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/704c/11875588/2cad67e692fe/medi-104-e41664-g005.jpg

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