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采用液相色谱-串联质谱法检测干燥人血中的葡萄糖醛酸乙酯。

Detection of ethyl glucuronide in dried human blood using LC-MS/MS.

作者信息

Kaufmann Eckhard, Alt Andreas

机构信息

Department of General Physiology, University of Ulm, Albert-Einstein-Allee 11, 89081 Ulm, Germany.

出版信息

Int J Legal Med. 2008 May;122(3):245-9. doi: 10.1007/s00414-007-0219-x. Epub 2008 Jan 5.

DOI:10.1007/s00414-007-0219-x
PMID:18180941
Abstract

Ethyl glucuronide, as a direct metabolite of ethanol degradation, has proven useful as a long-term marker in many forensic applications. The inability to determine ethyl glucuronide in dried blood left a missing link in many investigations. Here, we describe a new method based on mass spectrometry in a Pauli-type ion trap in order to determine this substance in dried blood samples.

摘要

葡萄糖醛酸乙酯作为乙醇降解的直接代谢产物，已被证明在许多法医应用中是一种有用的长期标志物。无法测定干血中的葡萄糖醛酸乙酯在许多调查中留下了一个缺失环节。在此，我们描述了一种基于保里型离子阱质谱法的新方法，用于测定干血样本中的这种物质。

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本文引用的文献

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Biochemical markers of alcoholism.酒精中毒的生化标志物。
Clin Chem Lab Med. 2007;45(8):953-61. doi: 10.1515/CCLM.2007.190.
2
Kinetics in serum and urinary excretion of ethyl sulfate and ethyl glucuronide after medium dose ethanol intake.中等剂量乙醇摄入后硫酸乙酯和葡萄糖醛酸乙酯在血清中的动力学及尿排泄情况。
Int J Legal Med. 2008 Mar;122(2):123-8. doi: 10.1007/s00414-007-0180-8. Epub 2007 Jun 9.
3
Sensitivity of commercial ethyl glucuronide (ETG) testing in screening for alcohol abstinence.商业性乙基葡萄糖醛酸苷（ETG）检测在筛查戒酒情况中的敏感性。
Alcohol Alcohol. 2007 Jul-Aug;42(4):317-20. doi: 10.1093/alcalc/agm014. Epub 2007 Mar 21.
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Ethyl glucuronide and ethyl sulphate determination in serum by liquid chromatography-electrospray tandem mass spectrometry.液相色谱-电喷雾串联质谱法测定血清中的葡萄糖醛酸乙酯和硫酸乙酯
Clin Chim Acta. 2007 Feb;376(1-2):213-9. doi: 10.1016/j.cca.2006.08.024. Epub 2006 Sep 29.
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Determination of GHB in urine and serum by LC/MS using a simple one-step derivative.采用简单的一步衍生化法通过液相色谱/质谱联用技术测定尿液和血清中的γ-羟基丁酸。
Forensic Sci Int. 2007 May 24;168(2-3):133-7. doi: 10.1016/j.forsciint.2006.07.002. Epub 2006 Sep 5.
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Interpreting results of ethanol analysis in postmortem specimens: a review of the literature.解读死后标本中乙醇分析结果：文献综述
Forensic Sci Int. 2007 Jan 5;165(1):10-29. doi: 10.1016/j.forsciint.2006.05.004. Epub 2006 Jun 19.
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State of the art in hair analysis for detection of drug and alcohol abuse.用于检测药物和酒精滥用的毛发分析技术现状。
Clin Chim Acta. 2006 Aug;370(1-2):17-49. doi: 10.1016/j.cca.2006.02.019. Epub 2006 Mar 6.
8
Stability of ethyl glucuronide in urine, post-mortem tissue and blood samples.尿液、死后组织及血液样本中葡萄糖醛酸乙酯的稳定性。
Int J Legal Med. 2006 Mar;120(2):83-8. doi: 10.1007/s00414-005-0012-7. Epub 2005 Jul 30.
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Ethyl glucuronide--the direct ethanol metabolite on the threshold from science to routine use.葡萄糖醛酸乙酯——从科学研究到常规应用临界阶段的直接乙醇代谢产物。
Addiction. 2003 Dec;98 Suppl 2:51-61. doi: 10.1046/j.1359-6357.2003.00588.x.
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Confirmatory analysis of ethylglucuronide in urine by liquid-chromatography/electrospray ionization/tandem mass spectrometry according to forensic guidelines.根据法医指南，采用液相色谱/电喷雾电离/串联质谱法对尿液中的乙基葡萄糖醛酸进行确证分析。
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