Haeffel Gerald J, Getchell Marya, Koposov Roman A, Yrigollen Carolyn M, Deyoung Colin G, Klinteberg Britt Af, Oreland Lars, Ruchkin Vladislav V, Grigorenko Elena L
University of Notre Dame, Notre Dame, IN 46556, USA.
Psychol Sci. 2008 Jan;19(1):62-9. doi: 10.1111/j.1467-9280.2008.02047.x.
Previous research has generated examples of how genetic and environmental factors can interact to create risk for psychopathology. Using a gene-by-environment (G x E) interaction design, we tested whether three polymorphisms in the dopamine transporter gene (DAT1, also referred to as SLC6A3, located at 5p15.33) interacted with maternal parenting style to predict first-onset episodes of depression. Participants were male adolescents (N= 176) recruited from a juvenile detention center in northern Russia. As hypothesized, one of the polymorphisms (rs40184) moderated the effect of perceived maternal rejection on the onset of major depressive disorder, as well as on suicidal ideation. Further, this G x E interaction was specific to depression; it did not predict clinically significant anxiety. These results highlight the need for further research investigating the moderating effects of dopaminergic genes on depression.
先前的研究已经给出了一些例子，说明基因和环境因素如何相互作用，从而产生精神病理学风险。我们采用基因-环境（G×E）相互作用设计，测试了多巴胺转运体基因（DAT1，也称为SLC6A3，位于5p15.33）中的三种多态性是否与母亲的养育方式相互作用，以预测首次发作的抑郁症。参与者为从俄罗斯北部一个青少年拘留中心招募的男性青少年（N = 176）。正如所假设的那样，其中一种多态性（rs40184）调节了母亲拒绝感对重度抑郁症发作以及自杀意念的影响。此外，这种G×E相互作用是抑郁症特有的；它并不能预测具有临床意义的焦虑症。这些结果凸显了进一步研究多巴胺能基因对抑郁症调节作用的必要性。
