Fahey B J, Nelson R C, Bradway D P, Hsu S J, Dumont D M, Trahey G E
Department of Biomedical Engineering, Duke University, Durham, NC, USA.
Department of Radiology, Duke University, Durham, NC, USA.
Phys Med Biol. 2008 Jan 7;53(1):279-93. doi: 10.1088/0031-9155/53/1/020. Epub 2007 Dec 19.
The utility of acoustic radiation force impulse (ARFI) imaging for real-time visualization of abdominal malignancies was investigated. Nine patients presenting with suspicious masses in the liver (n = 7) or kidney (n = 2) underwent combined sonography/ARFI imaging. Images were acquired of a total of 12 tumors in the nine patients. In all cases, boundary definition in ARFI images was improved or equivalent to boundary definition in B-mode images. Displacement contrast in ARFI images was superior to echo contrast in B-mode images for each tumor. The mean contrast for suspected hepatocellular carcinomas (HCCs) in B-mode images was 2.9 dB (range: 1.5-4.2) versus 7.5 dB (range: 3.1-11.9) in ARFI images, with all HCCs appearing more compliant than regional cirrhotic liver parenchyma. The mean contrast for metastases in B-mode images was 3.1 dB (range: 1.2-5.2) versus 9.3 dB (range: 5.7-13.9) in ARFI images, with all masses appearing less compliant than regional non-cirrhotic liver parenchyma. ARFI image contrast (10.4 dB) was superior to B-mode contrast (0.9 dB) for a renal mass. To our knowledge, we present the first in vivo images of abdominal malignancies in humans acquired with the ARFI method or any other technique of imaging tissue elasticity.
研究了声辐射力脉冲（ARFI）成像在腹部恶性肿瘤实时可视化中的应用价值。9例肝脏（n = 7）或肾脏（n = 2）出现可疑肿块的患者接受了超声/ARFI联合成像检查。共获取了9例患者12个肿瘤的图像。在所有病例中，ARFI图像中的边界清晰度均有所改善或与B模式图像中的边界清晰度相当。对于每个肿瘤，ARFI图像中的位移对比度均优于B模式图像中的回声对比度。B模式图像中疑似肝细胞癌（HCC）的平均对比度为2.9 dB（范围：1.5 - 4.2），而ARFI图像中为7.5 dB（范围：3.1 - 11.9），所有HCC均比局部肝硬化肝实质更具弹性。B模式图像中转移瘤的平均对比度为3.1 dB（范围：1.2 - 5.2），而ARFI图像中为9.3 dB（范围：5.7 - 13.9），所有肿块均比局部非肝硬化肝实质弹性更小。对于一个肾脏肿块，ARFI图像对比度（10.4 dB）优于B模式对比度（0.9 dB）。据我们所知，我们展示了通过ARFI方法或任何其他组织弹性成像技术获取的人类腹部恶性肿瘤的首批体内图像。
