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分析衰老和成纤维细胞对前列腺癌发生的影响。

Profiling influences of senescent and aged fibroblasts on prostate carcinogenesis.

作者信息

Dean J P, Nelson P S

机构信息

Division of Human Biology, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA.

出版信息

Br J Cancer. 2008 Jan 29;98(2):245-9. doi: 10.1038/sj.bjc.6604087. Epub 2008 Jan 8.

DOI:10.1038/sj.bjc.6604087
PMID:18182995
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2361445/
Abstract

Experimental evidence suggests that ageing-associated alterations in the tissue microenvironment act to promote prostate carcinogenesis. In this review, we survey the cellular state of senescence, review its causes, and describe associations with ageing and cancer. We further discuss senescent stromal gene expression changes, which may mediate these effects, and that may serve as therapeutic targets.

摘要

实验证据表明，组织微环境中与衰老相关的改变会促进前列腺癌的发生。在这篇综述中，我们研究了衰老细胞状态，回顾了其成因，并描述了与衰老和癌症的关联。我们还进一步讨论了衰老的基质基因表达变化，这些变化可能介导了这些效应，并且可能成为治疗靶点。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e313/2361445/95efe3fb62aa/6604087f2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e313/2361445/bf34e088d731/6604087f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e313/2361445/95efe3fb62aa/6604087f2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e313/2361445/bf34e088d731/6604087f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e313/2361445/95efe3fb62aa/6604087f2.jpg

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本文引用的文献

1
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2
Molecular signaling and genetic pathways of senescence: Its role in tumorigenesis and aging.衰老的分子信号传导与遗传通路：其在肿瘤发生和衰老中的作用
J Cell Physiol. 2007 Mar;210(3):567-74. doi: 10.1002/jcp.20919.
3
The chemokine growth-regulated oncogene 1 (Gro-1) links RAS signaling to the senescence of stromal fibroblasts and ovarian tumorigenesis.趋化因子生长调节致癌基因1（Gro-1）将RAS信号传导与基质成纤维细胞的衰老及卵巢肿瘤发生联系起来。
人参皂苷Rg3通过下调白细胞介素8的表达来抑制前列腺基质细胞的衰老。
Oncotarget. 2017 May 4;8(39):64779-64792. doi: 10.18632/oncotarget.17616. eCollection 2017 Sep 12.
4
Lower levels of interleukin-1β gene expression are associated with impaired Langerhans' cell migration in aged human skin.白细胞介素-1β基因表达水平较低与老年人皮肤中朗格汉斯细胞迁移受损有关。
Immunology. 2018 Jan;153(1):60-70. doi: 10.1111/imm.12810. Epub 2017 Aug 31.
5
The Tumor Microenvironment at a Turning Point Knowledge Gained Over the Last Decade, and Challenges and Opportunities Ahead: A White Paper from the NCI TME Network.肿瘤微环境处于转折点：过去十年所获知识以及未来的挑战与机遇——来自美国国立癌症研究所肿瘤微环境网络的白皮书
Cancer Res. 2017 Mar 1;77(5):1051-1059. doi: 10.1158/0008-5472.CAN-16-1336. Epub 2017 Feb 16.
6
Quantitation and Identification of Thousands of Human Proteoforms below 30 kDa.30 kDa以下数千种人类蛋白质变体的定量与鉴定
J Proteome Res. 2016 Mar 4;15(3):976-82. doi: 10.1021/acs.jproteome.5b00997. Epub 2016 Feb 11.
7
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4
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5
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