Lewis Claire E, Pollard Jeffrey W
Academic Unit of Pathology, Division of Genomic Medicine, University of Sheffield Medical School, Beech Hill Road, Sheffield S10 2RX, United Kingdom.
Cancer Res. 2006 Jan 15;66(2):605-12. doi: 10.1158/0008-5472.CAN-05-4005.
Macrophages are prominent in the stromal compartment of virtually all types of malignancy. These highly versatile cells respond to the presence of stimuli in different parts of tumors with the release of a distinct repertoire of growth factors, cytokines, chemokines, and enzymes that regulate tumor growth, angiogenesis, invasion, and/or metastasis. The distinct microenvironments where tumor-associated macrophages (TAM) act include areas of invasion where TAMs promote cancer cell motility, stromal and perivascular areas where TAMs promote metastasis, and avascular and perinecrotic areas where hypoxic TAMs stimulate angiogenesis. This review will discuss the evidence for differential regulation of TAMs in these microenvironments and provide an overview of current attempts to target or use TAMs for therapeutic purposes.
巨噬细胞在几乎所有类型恶性肿瘤的基质区室中都很突出。这些高度多功能的细胞对肿瘤不同部位的刺激作出反应，释放出一系列独特的生长因子、细胞因子、趋化因子和酶，从而调节肿瘤生长、血管生成、侵袭和/或转移。肿瘤相关巨噬细胞（TAM）发挥作用的不同微环境包括TAM促进癌细胞运动的侵袭区域、TAM促进转移的基质和血管周围区域，以及缺氧TAM刺激血管生成的无血管和坏死周围区域。本综述将讨论这些微环境中TAM差异调节的证据，并概述目前针对TAM或利用TAM进行治疗的尝试。
