Vandelli M A, Forni F, Coppi G, Cameroni R
Department of Pharmaceutical Sciences, University of Modena, Italy.
Pharmazie. 1991 Dec;46(12):866-9.
The cross-linking time period affected both the swelling and release processes of cross-linked gelatin microspheres. In the dynamic swelling procedure, the combination of both phenomena of microparticle swelling and drug diffusion produced at first the increase and then the decrease of the diameter of a loaded microsphere. The increase of the cross-linking time period produced the shift of the penetrant transport from anomalous to super-case II kinetics. This behaviour could justify the decrease of the diffusion component of the drug release as the cross-linking time period increased.
交联时间段影响交联明胶微球的溶胀和释放过程。在动态溶胀过程中，微粒溶胀和药物扩散这两种现象的结合首先使载药微球的直径增大，随后减小。交联时间段的增加使渗透物的传输从反常动力学转变为超Ⅱ型动力学。这种行为可以解释随着交联时间段增加药物释放扩散成分减少的现象。
