Forni F, Vandelli M A, Cameroni R
Department of Pharmaceutical Sciences, University of Modena, Italy.
J Microencapsul. 1992 Jan-Mar;9(1):29-39. doi: 10.3109/02652049209021220.
The effect of drug loading level both on dynamic swelling and drug release was evaluated using crosslinked gelatin microspheres. Owing to water penetration the microsphere diameter went first to a maximum value, which was not affected by the payload; the diameter gradually approached to an equilibrium swollen value, which was affected by drug loading level. Water absorption increases and drug diffusion decreases the microsphere diameter. Obviously, the diameter variation depends on the factor (water absorption or drug diffusion) predominating in the process. As the payload affected only the equilibrium swollen value it is reasonable to hypothesize that drug loading level has a greater effect on drug diffusion than on polymer relaxation. This rationale could explain the increase of the diffusion component of the drug release process as the payload increased.
使用交联明胶微球评估载药量对动态溶胀和药物释放的影响。由于水的渗透，微球直径首先达到最大值，该值不受载药量的影响；直径逐渐接近平衡溶胀值，该值受载药量的影响。吸水增加而药物扩散会减小微球直径。显然，直径变化取决于该过程中占主导的因素（吸水或药物扩散）。由于载药量仅影响平衡溶胀值，因此合理推测载药量对药物扩散的影响大于对聚合物松弛的影响。这一原理可以解释随着载药量增加药物释放过程中扩散成分的增加。
